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Hsp90 inhibitors reduce influenza virus replication in cell culture.

Chase G, Deng T, Fodor E, Leung BW, Mayer D, Schwemmle M, Brownlee G.

Virology. 2008 Aug 1;377(2):431-9. doi: 10.1016/j.virol.2008.04.040.


Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunits.

Naito T, Momose F, Kawaguchi A, Nagata K.

J Virol. 2007 Feb;81(3):1339-49. Epub 2006 Nov 22.


Packaging signals in the 5'-ends of influenza virus PA, PB1, and PB2 genes as potential targets to develop nucleic-acid based antiviral molecules.

Giannecchini S, Wise HM, Digard P, Clausi V, Del Poggetto E, Vesco L, Puzelli S, Donatelli I, Azzi A.

Antiviral Res. 2011 Oct;92(1):64-72. doi: 10.1016/j.antiviral.2011.06.013. Epub 2011 Jun 29.


Functional domains of the influenza A virus PB2 protein: identification of NP- and PB1-binding sites.

Poole E, Elton D, Medcalf L, Digard P.

Virology. 2004 Mar 30;321(1):120-33.


Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90.

Okamoto T, Nishimura Y, Ichimura T, Suzuki K, Miyamura T, Suzuki T, Moriishi K, Matsuura Y.

EMBO J. 2006 Oct 18;25(20):5015-25. Epub 2006 Oct 5. Erratum in: EMBO J. 2006 Nov 29;25(23):5634.


Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus.

He X, Zhou J, Bartlam M, Zhang R, Ma J, Lou Z, Li X, Li J, Joachimiak A, Zeng Z, Ge R, Rao Z, Liu Y.

Nature. 2008 Aug 28;454(7208):1123-6. doi: 10.1038/nature07120. Epub 2008 Jul 9.


Targeting of the influenza A virus polymerase PB1-PB2 interface indicates strain-specific assembly differences.

Reuther P, Mänz B, Brunotte L, Schwemmle M, Wunderlich K.

J Virol. 2011 Dec;85(24):13298-309. doi: 10.1128/JVI.00868-11. Epub 2011 Sep 28.


Fine mapping of the subunit binding sites of influenza virus RNA polymerase.

Ohtsu Y, Honda Y, Sakata Y, Kato H, Toyoda T.

Microbiol Immunol. 2002;46(3):167-75.


A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs.

Fodor E, Crow M, Mingay LJ, Deng T, Sharps J, Fechter P, Brownlee GG.

J Virol. 2002 Sep;76(18):8989-9001.


Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses.

Connor JH, McKenzie MO, Parks GD, Lyles DS.

Virology. 2007 May 25;362(1):109-19. Epub 2007 Jan 26.


Identification of Hsp90 as a stimulatory host factor involved in influenza virus RNA synthesis.

Momose F, Naito T, Yano K, Sugimoto S, Morikawa Y, Nagata K.

J Biol Chem. 2002 Nov 22;277(47):45306-14. Epub 2002 Sep 10.


HDAC6 inhibition enhances 17-AAG--mediated abrogation of hsp90 chaperone function in human leukemia cells.

Rao R, Fiskus W, Yang Y, Lee P, Joshi R, Fernandez P, Mandawat A, Atadja P, Bradner JE, Bhalla K.

Blood. 2008 Sep 1;112(5):1886-93. doi: 10.1182/blood-2008-03-143644. Epub 2008 Jun 30.


Role of heat-shock protein 90 in hepatitis E virus capsid trafficking.

Zheng ZZ, Miao J, Zhao M, Tang M, Yeo AE, Yu H, Zhang J, Xia NS.

J Gen Virol. 2010 Jul;91(Pt 7):1728-36. doi: 10.1099/vir.0.019323-0. Epub 2010 Mar 10.


The N terminus of PA polymerase of swine-origin influenza virus H1N1 determines its compatibility with PB2 and PB1 subunits through a strain-specific amino acid serine 186.

Wanitchang A, Jengarn J, Jongkaewwattana A.

Virus Res. 2011 Jan;155(1):325-33. doi: 10.1016/j.virusres.2010.10.032. Epub 2010 Nov 5.


A novel function of the N-terminal domain of PA in assembly of influenza A virus RNA polymerase.

Suzuki T, Ainai A, Nagata N, Sata T, Sawa H, Hasegawa H.

Biochem Biophys Res Commun. 2011 Nov 4;414(4):719-26. doi: 10.1016/j.bbrc.2011.09.142. Epub 2011 Oct 6.


Mapping the domain structure of the influenza A virus polymerase acidic protein (PA) and its interaction with the basic protein 1 (PB1) subunit.

Guu TS, Dong L, Wittung-Stafshede P, Tao YJ.

Virology. 2008 Sep 15;379(1):135-42. doi: 10.1016/j.virol.2008.06.022. Epub 2008 Jul 26.


Peptide-mediated interference with influenza A virus polymerase.

Ghanem A, Mayer D, Chase G, Tegge W, Frank R, Kochs G, García-Sastre A, Schwemmle M.

J Virol. 2007 Jul;81(14):7801-4. Epub 2007 May 9.

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