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The NS1 protein of a human influenza virus inhibits type I interferon production and the induction of antiviral responses in primary human dendritic and respiratory epithelial cells.

Haye K, Burmakina S, Moran T, García-Sastre A, Fernandez-Sesma A.

J Virol. 2009 Jul;83(13):6849-62. doi: 10.1128/JVI.02323-08. Epub 2009 Apr 29.


Contribution of double-stranded RNA and CPSF30 binding domains of influenza virus NS1 to the inhibition of type I interferon production and activation of human dendritic cells.

Ramos I, Carnero E, Bernal-Rubio D, Seibert CW, Westera L, García-Sastre A, Fernandez-Sesma A.

J Virol. 2013 Mar;87(5):2430-40. doi: 10.1128/JVI.02247-12. Epub 2012 Dec 19.


NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses.

DeDiego ML, Nogales A, Lambert-Emo K, Martinez-Sobrido L, Topham DJ.

J Virol. 2016 Oct 14;90(21):9693-9711. Print 2016 Nov 1.


A Conserved Residue, Tyrosine (Y) 84, in H5N1 Influenza A Virus NS1 Regulates IFN Signaling Responses to Enhance Viral Infection.

Wang BX, Wei L, Kotra LP, Brown EG, Fish EN.

Viruses. 2017 May 12;9(5). pii: E107. doi: 10.3390/v9050107.


G45R on nonstructural protein 1 of influenza A virus contributes to virulence by increasing the expression of proinflammatory cytokines in mice.

Kaewborisuth C, Kaplan B, Zanin M, Finkelstein D, Webby RJ, Lekcharoensuk P.

Arch Virol. 2017 Jan;162(1):45-55. doi: 10.1007/s00705-016-3072-8. Epub 2016 Sep 23.


NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A Viruses.

Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML.

J Virol. 2017 Feb 14;91(5). pii: e01930-16. doi: 10.1128/JVI.01930-16. Print 2017 Mar 1.


Mammalian Adaptation of an Avian Influenza A Virus Involves Stepwise Changes in NS1.

Chauché C, Nogales A, Zhu H, Goldfarb D, Ahmad Shanizza AI, Gu Q, Parrish CR, Martínez-Sobrido L, Marshall JF, Murcia PR.

J Virol. 2018 Feb 12;92(5). pii: e01875-17. doi: 10.1128/JVI.01875-17. Print 2018 Mar 1.


Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes.

Ferko B, Stasakova J, Romanova J, Kittel C, Sereinig S, Katinger H, Egorov A.

J Virol. 2004 Dec;78(23):13037-45.


Multiple anti-interferon actions of the influenza A virus NS1 protein.

Kochs G, García-Sastre A, Martínez-Sobrido L.

J Virol. 2007 Jul;81(13):7011-21. Epub 2007 Apr 18.


An A14U Substitution in the 3' Noncoding Region of the M Segment of Viral RNA Supports Replication of Influenza Virus with an NS1 Deletion by Modulating Alternative Splicing of M Segment mRNAs.

Zheng M, Wang P, Song W, Lau SY, Liu S, Huang X, Mok BW, Liu YC, Chen Y, Yuen KY, Chen H.

J Virol. 2015 Oct;89(20):10273-85. doi: 10.1128/JVI.00919-15. Epub 2015 Jul 29.


Analysis of cytokine production in a newly developed canine tracheal epithelial cell line infected with H3N2 canine influenza virus.

Park WJ, Park BJ, Song YJ, Lee DH, Yuk SS, Lee JB, Park SY, Song CS, Lee SW, Choi IS.

Arch Virol. 2015 Jun;160(6):1397-405. doi: 10.1007/s00705-015-2395-1. Epub 2015 Mar 24.


Influenza virus NS1 protein mutations at position 171 impact innate interferon responses by respiratory epithelial cells.

Plant EP, Ilyushina NA, Sheikh F, Donnelly RP, Ye Z.

Virus Res. 2017 Aug 15;240:81-86. doi: 10.1016/j.virusres.2017.07.021. Epub 2017 Jul 27.


Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein.

Hale BG, Steel J, Medina RA, Manicassamy B, Ye J, Hickman D, Hai R, Schmolke M, Lowen AC, Perez DR, García-Sastre A.

J Virol. 2010 Jul;84(14):6909-22. doi: 10.1128/JVI.00081-10. Epub 2010 May 5.


The K186E Amino Acid Substitution in the Canine Influenza Virus H3N8 NS1 Protein Restores Its Ability To Inhibit Host Gene Expression.

Nogales A, Chauché C, DeDiego ML, Topham DJ, Parrish CR, Murcia PR, Martínez-Sobrido L.

J Virol. 2017 Oct 27;91(22). pii: e00877-17. doi: 10.1128/JVI.00877-17. Print 2017 Nov 15.


Influenza virus evades innate and adaptive immunity via the NS1 protein.

Fernandez-Sesma A, Marukian S, Ebersole BJ, Kaminski D, Park MS, Yuen T, Sealfon SC, García-Sastre A, Moran TM.

J Virol. 2006 Jul;80(13):6295-304.


Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems.

García-Sastre A, Egorov A, Matassov D, Brandt S, Levy DE, Durbin JE, Palese P, Muster T.

Virology. 1998 Dec 20;252(2):324-30.


Key role of regulated upon activation normal T-cell expressed and secreted, nonstructural protein1 and myeloperoxidase in cytokine storm induced by influenza virus PR-8 (A/H1N1) infection in A549 bronchial epithelial cells.

Phung TT, Sugamata R, Uno K, Aratani Y, Ozato K, Kawachi S, Thanh Nguyen L, Nakayama T, Suzuki K.

Microbiol Immunol. 2011 Dec;55(12):874-84. doi: 10.1111/j.1348-0421.2011.00396.x.


Properties of H7N7 influenza A virus strain SC35M lacking interferon antagonist NS1 in mice and chickens.

Kochs G, Koerner I, Thiel L, Kothlow S, Kaspers B, Ruggli N, Summerfield A, Pavlovic J, Stech J, Staeheli P.

J Gen Virol. 2007 May;88(Pt 5):1403-9.


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