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Items: 1 to 20 of 127

1.

A critical role for TNF receptor-associated factor 1 and Bim down-regulation in CD8 memory T cell survival.

Sabbagh L, Srokowski CC, Pulle G, Snell LM, Sedgmen BJ, Liu Y, Tsitsikov EN, Watts TH.

Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18703-8. Epub 2006 Nov 20.

2.

ERK-dependent Bim modulation downstream of the 4-1BB-TRAF1 signaling axis is a critical mediator of CD8 T cell survival in vivo.

Sabbagh L, Pulle G, Liu Y, Tsitsikov EN, Watts TH.

J Immunol. 2008 Jun 15;180(12):8093-101.

3.

Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells.

Sabbagh L, Andreeva D, Laramée GD, Oussa NA, Lew D, Bisson N, Soumounou Y, Pawson T, Watts TH.

J Leukoc Biol. 2013 May;93(5):713-21. doi: 10.1189/jlb.1112579. Epub 2013 Feb 27.

PMID:
23446150
4.

Bcl-2 allows effector and memory CD8+ T cells to tolerate higher expression of Bim.

Kurtulus S, Tripathi P, Moreno-Fernandez ME, Sholl A, Katz JD, Grimes HL, Hildeman DA.

J Immunol. 2011 May 15;186(10):5729-37. doi: 10.4049/jimmunol.1100102. Epub 2011 Mar 30.

5.

Opposing roles for TRAF1 in the alternative versus classical NF-κB pathway in T cells.

McPherson AJ, Snell LM, Mak TW, Watts TH.

J Biol Chem. 2012 Jun 29;287(27):23010-9. doi: 10.1074/jbc.M112.350538. Epub 2012 May 8.

6.

CD70-driven costimulation induces survival or Fas-mediated apoptosis of T cells depending on antigenic load.

Wensveen FM, Unger PP, Kragten NA, Derks IA, ten Brinke A, Arens R, van Lier RA, Eldering E, van Gisbergen KP.

J Immunol. 2012 May 1;188(9):4256-67. doi: 10.4049/jimmunol.1102889. Epub 2012 Mar 26.

7.

Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection.

Wang C, McPherson AJ, Jones RB, Kawamura KS, Lin GH, Lang PA, Ambagala T, Pellegrini M, Calzascia T, Aidarus N, Elford AR, Yue FY, Kremmer E, Kovacs CM, Benko E, Tremblay C, Routy JP, Bernard NF, Ostrowski MA, Ohashi PS, Watts TH.

J Exp Med. 2012 Jan 16;209(1):77-91. doi: 10.1084/jem.20110675. Epub 2011 Dec 19.

8.

Intrinsic role of FoxO3a in the development of CD8+ T cell memory.

Tzelepis F, Joseph J, Haddad EK, Maclean S, Dudani R, Agenes F, Peng SL, Sekaly RP, Sad S.

J Immunol. 2013 Feb 1;190(3):1066-75. doi: 10.4049/jimmunol.1200639. Epub 2012 Dec 31.

9.

MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation.

O'Reilly LA, Kruse EA, Puthalakath H, Kelly PN, Kaufmann T, Huang DC, Strasser A.

J Immunol. 2009 Jul 1;183(1):261-9. doi: 10.4049/jimmunol.0803853.

10.

BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway.

Craxton A, Draves KE, Gruppi A, Clark EA.

J Exp Med. 2005 Nov 21;202(10):1363-74.

11.

Role of Bim in regulating CD8+ T-cell responses during chronic viral infection.

Grayson JM, Weant AE, Holbrook BC, Hildeman D.

J Virol. 2006 Sep;80(17):8627-38.

12.
13.
15.

Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins.

Kurtulus S, Sholl A, Toe J, Tripathi P, Raynor J, Li KP, Pellegrini M, Hildeman DA.

Cell Death Differ. 2015 Jan;22(1):174-84. doi: 10.1038/cdd.2014.118. Epub 2014 Aug 15.

16.

LFA-1 defect-induced effector/memory CD8+ T cell apoptosis is mediated via Bcl-2/Caspase pathways and associated with downregulation of CD27 and IL-15R.

Ye Z, Shi M, Xu S, Xiang J.

Mol Immunol. 2010 Aug;47(14):2411-21. doi: 10.1016/j.molimm.2010.02.005. Epub 2010 May 31.

PMID:
20569988
17.

The Pim kinase pathway contributes to survival signaling in primed CD8+ T cells upon CD27 costimulation.

Peperzak V, Veraar EA, Keller AM, Xiao Y, Borst J.

J Immunol. 2010 Dec 1;185(11):6670-8. doi: 10.4049/jimmunol.1000159. Epub 2010 Nov 3.

18.

Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis.

Wojciechowski S, Tripathi P, Bourdeau T, Acero L, Grimes HL, Katz JD, Finkelman FD, Hildeman DA.

J Exp Med. 2007 Jul 9;204(7):1665-75. Epub 2007 Jun 25.

19.

The Erk2 MAPK regulates CD8 T cell proliferation and survival.

D'Souza WN, Chang CF, Fischer AM, Li M, Hedrick SM.

J Immunol. 2008 Dec 1;181(11):7617-29.

20.

Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis.

Schwulst SJ, Muenzer JT, Peck-Palmer OM, Chang KC, Davis CG, McDonough JS, Osborne DF, Walton AH, Unsinger J, McDunn JE, Hotchkiss RS.

Shock. 2008 Aug;30(2):127-34. doi: 10.1097/shk.0b013e318162cf17.

PMID:
18197142

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