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Hyaluronidase expression induces prostate tumor metastasis in an orthotopic mouse model.

Kovar JL, Johnson MA, Volcheck WM, Chen J, Simpson MA.

Am J Pathol. 2006 Oct;169(4):1415-26.


HYAL1 hyaluronidase in prostate cancer: a tumor promoter and suppressor.

Lokeshwar VB, Cerwinka WH, Isoyama T, Lokeshwar BL.

Cancer Res. 2005 Sep 1;65(17):7782-9.


Spontaneous metastasis of prostate cancer is promoted by excess hyaluronan synthesis and processing.

Bharadwaj AG, Kovar JL, Loughman E, Elowsky C, Oakley GG, Simpson MA.

Am J Pathol. 2009 Mar;174(3):1027-36. doi: 10.2353/ajpath.2009.080501. Epub 2009 Feb 13.


Orthotopic treatment model of prostate cancer and metastasis in the immunocompetent mouse: efficacy of flt3 ligand immunotherapy.

Somers KD, Brown RR, Holterman DA, Yousefieh N, Glass WF, Wright GL Jr, Schellhammer PF, Qian J, Ciavarra RP.

Int J Cancer. 2003 Dec 10;107(5):773-80.


An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor line.

Wang Y, Xue H, Cutz JC, Bayani J, Mawji NR, Chen WG, Goetz LJ, Hayward SW, Sadar MD, Gilks CB, Gout PW, Squire JA, Cunha GR, Wang YZ.

Lab Invest. 2005 Nov;85(11):1392-404.


Systemic interleukin 2 therapy for human prostate tumors in a nude mouse model.

Triest JA, Grignon DJ, Cher ML, Kocheril SV, Montecillo EJ, Talati B, Tekyi-Mensah S, Pontes JE, Hillman GG.

Clin Cancer Res. 1998 Aug;4(8):2009-14.


Alendronate decreases orthotopic PC-3 prostate tumor growth and metastasis to prostate-draining lymph nodes in nude mice.

Tuomela JM, Valta MP, Väänänen K, Härkönen PL.

BMC Cancer. 2008 Mar 28;8:81. doi: 10.1186/1471-2407-8-81.


Metastatic model for human prostate cancer using orthotopic implantation in nude mice.

Stephenson RA, Dinney CP, Gohji K, Ordóñez NG, Killion JJ, Fidler IJ.

J Natl Cancer Inst. 1992 Jun 17;84(12):951-7.


Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice.

Pettaway CA, Pathak S, Greene G, Ramirez E, Wilson MR, Killion JJ, Fidler IJ.

Clin Cancer Res. 1996 Sep;2(9):1627-36.


Overexpression of vascular endothelial growth factor C increases growth and alters the metastatic pattern of orthotopic PC-3 prostate tumors.

Tuomela J, Valta M, Seppänen J, Tarkkonen K, Väänänen HK, Härkönen P.

BMC Cancer. 2009 Oct 12;9:362. doi: 10.1186/1471-2407-9-362.


Real-time whole-body imaging of an orthotopic metastatic prostate cancer model expressing red fluorescent protein.

Yang M, Jiang P, Yamamoto N, Li L, Geller J, Moossa AR, Hoffman RM.

Prostate. 2005 Mar 1;62(4):374-9.


Hyaluronidase gene profiling and role of hyal-1 overexpression in an orthotopic model of prostate cancer.

Patel S, Turner PR, Stubberfield C, Barry E, Rohlff CR, Stamps A, McKenzie E, Young K, Tyson K, Terrett J, Box G, Eccles S, Page MJ.

Int J Cancer. 2002 Feb 1;97(4):416-24. Erratum in: Int J Cancer 2002 Apr 20;98(6):957.


HYAL1 overexpression is correlated with the malignant behavior of human breast cancer.

Tan JX, Wang XY, Li HY, Su XL, Wang L, Ran L, Zheng K, Ren GS.

Int J Cancer. 2011 Mar 15;128(6):1303-15. doi: 10.1002/ijc.25460.


Prostate cancer treatment is enhanced by genistein in vitro and in vivo in a syngeneic orthotopic tumor model.

Wang Y, Raffoul JJ, Che M, Doerge DR, Joiner MC, Kucuk O, Sarkar FH, Hillman GG.

Radiat Res. 2006 Jul;166(1 Pt 1):73-80.


HYAL1 hyaluronidase: a molecular determinant of bladder tumor growth and invasion.

Lokeshwar VB, Cerwinka WH, Lokeshwar BL.

Cancer Res. 2005 Mar 15;65(6):2243-50.

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