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Biophysical characterization of the complex between double-stranded RNA and the N-terminal domain of the NS1 protein from influenza A virus: evidence for a novel RNA-binding mode.

Chien CY, Xu Y, Xiao R, Aramini JM, Sahasrabudhe PV, Krug RM, Montelione GT.

Biochemistry. 2004 Feb 24;43(7):1950-62.


Conserved surface features form the double-stranded RNA binding site of non-structural protein 1 (NS1) from influenza A and B viruses.

Yin C, Khan JA, Swapna GV, Ertekin A, Krug RM, Tong L, Montelione GT.

J Biol Chem. 2007 Jul 13;282(28):20584-92. Epub 2007 May 1.


G45R mutation in the nonstructural protein 1 of A/Puerto Rico/8/1934 (H1N1) enhances viral replication independent of dsRNA-binding activity and type I interferon biology.

Kaewborisuth C, Zanin M, Häcker H, Webby RJ, Lekcharoensuk P.

Virol J. 2016 Jul 12;13:127. doi: 10.1186/s12985-016-0585-4.


ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells.

Zhao C, Hsiang TY, Kuo RL, Krug RM.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2253-8. doi: 10.1073/pnas.0909144107. Epub 2010 Jan 19.


Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferon.

Wang X, Li M, Zheng H, Muster T, Palese P, Beg AA, García-Sastre A.

J Virol. 2000 Dec;74(24):11566-73.


NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses.

DeDiego ML, Nogales A, Lambert-Emo K, Martinez-Sobrido L, Topham DJ.

J Virol. 2016 Oct 14;90(21):9693-9711. Print 2016 Nov 1.


Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon.

Birdwell LD, Zalinger ZB, Li Y, Wright PW, Elliott R, Rose KM, Silverman RH, Weiss SR.

J Virol. 2016 Jan 6;90(6):3160-72. doi: 10.1128/JVI.03036-15.


Dimer interface of the effector domain of non-structural protein 1 from influenza A virus: an interface with multiple functions.

Aramini JM, Ma LC, Zhou L, Schauder CM, Hamilton K, Amer BR, Mack TR, Lee HW, Ciccosanti CT, Zhao L, Xiao R, Krug RM, Montelione GT.

J Biol Chem. 2011 Jul 22;286(29):26050-60. doi: 10.1074/jbc.M111.248765. Epub 2011 May 26.


Cell-type-specific effects of RNase L on viral induction of beta interferon.

Banerjee S, Chakrabarti A, Jha BK, Weiss SR, Silverman RH.

MBio. 2014 Feb 25;5(2):e00856-14. doi: 10.1128/mBio.00856-14.


The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cells.

Twu KY, Kuo RL, Marklund J, Krug RM.

J Virol. 2007 Aug;81(15):8112-21. Epub 2007 May 23.


The CPSF30 binding site on the NS1A protein of influenza A virus is a potential antiviral target.

Twu KY, Noah DL, Rao P, Kuo RL, Krug RM.

J Virol. 2006 Apr;80(8):3957-65.

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