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Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation.

Yamasaki E, Wada A, Kumatori A, Nakagawa I, Funao J, Nakayama M, Hisatsune J, Kimura M, Moss J, Hirayama T.

J Biol Chem. 2006 Apr 21;281(16):11250-9. Epub 2006 Jan 25.


Endosome-mitochondria juxtaposition during apoptosis induced by H. pylori VacA.

Calore F, Genisset C, Casellato A, Rossato M, Codolo G, Esposti MD, Scorrano L, de Bernard M.

Cell Death Differ. 2010 Nov;17(11):1707-16. doi: 10.1038/cdd.2010.42. Epub 2010 Apr 30.


Activation of Bak and Bax through c-abl-protein kinase Cdelta-p38 MAPK signaling in response to ionizing radiation in human non-small cell lung cancer cells.

Choi SY, Kim MJ, Kang CM, Bae S, Cho CK, Soh JW, Kim JH, Kang S, Chung HY, Lee YS, Lee SJ.

J Biol Chem. 2006 Mar 17;281(11):7049-59. Epub 2006 Jan 12.


Helicobacter pylori VacA activates the p38/activating transcription factor 2-mediated signal pathway in AZ-521 cells.

Nakayama M, Kimura M, Wada A, Yahiro K, Ogushi K, Niidome T, Fujikawa A, Shirasaka D, Aoyama N, Kurazono H, Noda M, Moss J, Hirayama T.

J Biol Chem. 2004 Feb 20;279(8):7024-8. Epub 2003 Nov 20.


Helicobacter pylori VacA reduces the cellular expression of STAT3 and pro-survival Bcl-2 family proteins, Bcl-2 and Bcl-XL, leading to apoptosis in gastric epithelial cells.

Matsumoto A, Isomoto H, Nakayama M, Hisatsune J, Nishi Y, Nakashima Y, Matsushima K, Kurazono H, Nakao K, Hirayama T, Kohno S.

Dig Dis Sci. 2011 Apr;56(4):999-1006. doi: 10.1007/s10620-010-1420-1. Epub 2010 Oct 7.


Helicobacter pylori vacuolating cytotoxin A (VacA) engages the mitochondrial fission machinery to induce host cell death.

Jain P, Luo ZQ, Blanke SR.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16032-7. doi: 10.1073/pnas.1105175108. Epub 2011 Sep 8.


Benzo(a)pyrene-7,8-diol-9,10-epoxide induced p53-independent necrosis via the mitochondria-associated pathway involving Bax and Bak activation.

Zhang W, Liu N, Wang X, Jin X, Du H, Peng G, Xue J.

Hum Exp Toxicol. 2015 Feb;34(2):179-90. doi: 10.1177/0960327114533358. Epub 2014 May 16.


The multidomain proapoptotic molecules Bax and Bak are directly activated by heat.

Pagliari LJ, Kuwana T, Bonzon C, Newmeyer DD, Tu S, Beere HM, Green DR.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17975-80. Epub 2005 Dec 5.


Dual effects of Helicobacter pylori vacuolating cytotoxin on human eosinophil apoptosis in early and late periods of stimulation.

Kim JM, Kim JS, Lee JY, Sim YS, Kim YJ, Oh YK, Yoon HJ, Kang JS, Youn J, Kim N, Jung HC, Kim S.

Eur J Immunol. 2010 Jun;40(6):1651-62. doi: 10.1002/eji.200939882.


Ionizing radiation utilizes c-Jun N-terminal kinase for amplification of mitochondrial apoptotic cell death in human cervical cancer cells.

Kim MJ, Lee KH, Lee SJ.

FEBS J. 2008 May;275(9):2096-108. doi: 10.1111/j.1742-4658.2008.06363.x. Epub 2008 Mar 28.


Tumor necrosis factor-alpha induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K.

Sundararajan R, Cuconati A, Nelson D, White E.

J Biol Chem. 2001 Nov 30;276(48):45120-7. Epub 2001 Sep 24.


Involvement of syntaxin 7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori-produced cytotoxin VacA.

Suzuki J, Ohnishi H, Wada A, Hirayama T, Ohno H, Ueda N, Yasuda H, Iiri T, Wada Y, Futai M, Mashima H.

J Biol Chem. 2003 Jul 11;278(28):25585-90. Epub 2003 Apr 30.


Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis.

Jiang X, Jiang H, Shen Z, Wang X.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14782-7. doi: 10.1073/pnas.1417253111. Epub 2014 Oct 1.


Bak and Bax are non-redundant during infection- and DNA damage-induced apoptosis.

Kepp O, Rajalingam K, Kimmig S, Rudel T.

EMBO J. 2007 Feb 7;26(3):825-34. Epub 2007 Jan 18.


The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release.

Galmiche A, Rassow J, Doye A, Cagnol S, Chambard JC, Contamin S, de Thillot V, Just I, Ricci V, Solcia E, Van Obberghen E, Boquet P.

EMBO J. 2000 Dec 1;19(23):6361-70.

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