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Items: 1 to 20 of 145

1.

Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling.

Macdonald A, Mazaleyrat S, McCormick C, Street A, Burgoyne NJ, Jackson RM, Cazeaux V, Shelton H, Saksela K, Harris M.

J Gen Virol. 2005 Apr;86(Pt 4):1035-44.

PMID:
15784897
2.

The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity.

Macdonald A, Crowder K, Street A, McCormick C, Harris M.

J Gen Virol. 2004 Mar;85(Pt 3):721-9.

PMID:
14993658
4.

The promiscuous binding of the Fyn SH3 domain to a peptide from the NS5A protein.

Martin-Garcia JM, Luque I, Ruiz-Sanz J, Camara-Artigas A.

Acta Crystallogr D Biol Crystallogr. 2012 Aug;68(Pt 8):1030-40. doi: 10.1107/S0907444912019798. Epub 2012 Jul 17.

PMID:
22868769
5.

Hepatitis C virus NS5A: tales of a promiscuous protein.

Macdonald A, Harris M.

J Gen Virol. 2004 Sep;85(Pt 9):2485-502. Review.

PMID:
15302943
6.

A conserved proline between domains II and III of hepatitis C virus NS5A influences both RNA replication and virus assembly.

Hughes M, Gretton S, Shelton H, Brown DD, McCormick CJ, Angus AG, Patel AH, Griffin S, Harris M.

J Virol. 2009 Oct;83(20):10788-96. doi: 10.1128/JVI.02406-08. Epub 2009 Aug 5.

7.

The NS5A protein of hepatitis C virus is a zinc metalloprotein.

Tellinghuisen TL, Marcotrigiano J, Gorbalenya AE, Rice CM.

J Biol Chem. 2004 Nov 19;279(47):48576-87. Epub 2004 Aug 31.

8.

The SH3 binding motif of HCV [corrected] NS5A protein interacts with Bin1 and is important for apoptosis and infectivity.

Nanda SK, Herion D, Liang TJ.

Gastroenterology. 2006 Mar;130(3):794-809. Erratum in: Gastroenterology. 2006 Aug;131(2):687.

PMID:
16530520
9.

Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B.

Hamamoto I, Nishimura Y, Okamoto T, Aizaki H, Liu M, Mori Y, Abe T, Suzuki T, Lai MM, Miyamura T, Moriishi K, Matsuura Y.

J Virol. 2005 Nov;79(21):13473-82.

10.

The hepatitis C virus non-structural NS5A protein inhibits activating protein-1 function by perturbing ras-ERK pathway signaling.

Macdonald A, Crowder K, Street A, McCormick C, Saksela K, Harris M.

J Biol Chem. 2003 May 16;278(20):17775-84. Epub 2003 Mar 5.

11.

The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade.

Street A, Macdonald A, Crowder K, Harris M.

J Biol Chem. 2004 Mar 26;279(13):12232-41. Epub 2004 Jan 5.

12.
13.

Structure of the c-Src-SH3 domain in complex with a proline-rich motif of NS5A protein from the hepatitis C virus.

Bacarizo J, Martínez-Rodríguez S, Cámara-Artigas A.

J Struct Biol. 2015 Jan;189(1):67-72. doi: 10.1016/j.jsb.2014.11.004. Epub 2014 Nov 25.

PMID:
25447263
14.

Phosphorylation of hepatitis C virus NS5A nonstructural protein: a new paradigm for phosphorylation-dependent viral RNA replication?

Huang Y, Staschke K, De Francesco R, Tan SL.

Virology. 2007 Jul 20;364(1):1-9. Epub 2007 Apr 2. Review.

16.

Natural genetic engineering of hepatitis C virus NS5A for immune system counterattack.

El Hefnawi MM, El Behaidy WH, Youssif AA, Ghalwash AZ, El Housseiny LA, Zada S.

Ann N Y Acad Sci. 2009 Oct;1178:173-85. doi: 10.1111/j.1749-6632.2009.05003.x.

PMID:
19845637
17.

RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef.

Arold S, O'Brien R, Franken P, Strub MP, Hoh F, Dumas C, Ladbury JE.

Biochemistry. 1998 Oct 20;37(42):14683-91.

PMID:
9778343
18.

Hepatitis C virus RNA polymerase and NS5A complex with a SNARE-like protein.

Tu H, Gao L, Shi ST, Taylor DR, Yang T, Mircheff AK, Wen Y, Gorbalenya AE, Hwang SB, Lai MM.

Virology. 1999 Oct 10;263(1):30-41.

19.

Transient structure and SH3 interaction sites in an intrinsically disordered fragment of the hepatitis C virus protein NS5A.

Feuerstein S, Solyom Z, Aladag A, Favier A, Schwarten M, Hoffmann S, Willbold D, Brutscher B.

J Mol Biol. 2012 Jul 20;420(4-5):310-23. doi: 10.1016/j.jmb.2012.04.023. Epub 2012 Apr 26.

PMID:
22543239
20.

c-Src is required for complex formation between the hepatitis C virus-encoded proteins NS5A and NS5B: a prerequisite for replication.

Pfannkuche A, Büther K, Karthe J, Poenisch M, Bartenschlager R, Trilling M, Hengel H, Willbold D, Häussinger D, Bode JG.

Hepatology. 2011 Apr;53(4):1127-36. doi: 10.1002/hep.24214.

PMID:
21480319

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