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4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses.

Dawicki W, Bertram EM, Sharpe AH, Watts TH.

J Immunol. 2004 Nov 15;173(10):5944-51.


During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion.

Hendriks J, Xiao Y, Rossen JW, van der Sluijs KF, Sugamura K, Ishii N, Borst J.

J Immunol. 2005 Aug 1;175(3):1665-76.


A switch in costimulation from CD28 to 4-1BB during primary versus secondary CD8 T cell response to influenza in vivo.

Bertram EM, Dawicki W, Sedgmen B, Bramson JL, Lynch DH, Watts TH.

J Immunol. 2004 Jan 15;172(2):981-8.


4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy.

Cannons JL, Lau P, Ghumman B, DeBenedette MA, Yagita H, Okumura K, Watts TH.

J Immunol. 2001 Aug 1;167(3):1313-24.


IL-15-dependent induction of 4-1BB promotes antigen-independent CD8 memory T cell survival.

Pulle G, Vidric M, Watts TH.

J Immunol. 2006 Mar 1;176(5):2739-48.


Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases.

Murata K, Nose M, Ndhlovu LC, Sato T, Sugamura K, Ishii N.

J Immunol. 2002 Oct 15;169(8):4628-36.


Evaluation of OX40 ligand as a costimulator of human antiviral memory CD8 T cell responses: comparison with B7.1 and 4-1BBL.

Serghides L, Bukczynski J, Wen T, Wang C, Routy JP, Boulassel MR, Sekaly RP, Ostrowski M, Bernard NF, Watts TH.

J Immunol. 2005 Nov 15;175(10):6368-77.


4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine.

Munks MW, Mourich DV, Mittler RS, Weinberg AD, Hill AB.

Immunology. 2004 Aug;112(4):559-66.


Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection.

Shedlock DJ, Whitmire JK, Tan J, MacDonald AS, Ahmed R, Shen H.

J Immunol. 2003 Feb 15;170(4):2053-63.


OX40-OX40 ligand interaction through T cell-T cell contact contributes to CD4 T cell longevity.

Soroosh P, Ine S, Sugamura K, Ishii N.

J Immunol. 2006 May 15;176(10):5975-87.


Functional dichotomy between OX40 and 4-1BB in modulating effector CD8 T cell responses.

Lee SW, Park Y, Song A, Cheroutre H, Kwon BS, Croft M.

J Immunol. 2006 Oct 1;177(7):4464-72.


4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses.

Tan JT, Whitmire JK, Ahmed R, Pearson TC, Larsen CP.

J Immunol. 1999 Nov 1;163(9):4859-68.


The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells.

Ma BY, Mikolajczak SA, Danesh A, Hosiawa KA, Cameron CM, Takaori-Kondo A, Uchiyama T, Kelvin DJ, Ochi A.

Blood. 2005 Sep 15;106(6):2002-10. Epub 2005 Jun 7.


Ligation of 4-1BB (CDw137) regulates graft-versus-host disease, graft-versus-leukemia, and graft rejection in allogeneic bone marrow transplant recipients.

Blazar BR, Kwon BS, Panoskaltsis-Mortari A, Kwak KB, Peschon JJ, Taylor PA.

J Immunol. 2001 Mar 1;166(5):3174-83.


Enhanced CD4 T cell responsiveness in the absence of 4-1BB.

Lee SW, Vella AT, Kwon BS, Croft M.

J Immunol. 2005 Jun 1;174(11):6803-8.


Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis.

Akiba H, Miyahira Y, Atsuta M, Takeda K, Nohara C, Futagawa T, Matsuda H, Aoki T, Yagita H, Okumura K.

J Exp Med. 2000 Jan 17;191(2):375-80.


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