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Items: 1 to 20 of 145

1.

Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.

Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H.

J Gen Virol. 2004 Apr;85(Pt 4):959-69.

PMID:
15039538
3.

Expression of hepatitis C virus NS5A natural mutants in a hepatocytic cell line inhibits the antiviral effect of interferon in a PKR-independent manner.

Podevin P, Sabile A, Gajardo R, Delhem N, Abadie A, Lozach PY, Beretta L, Bréchot C.

Hepatology. 2001 Jun;33(6):1503-11.

PMID:
11391540
4.

Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.

Gale M Jr, Blakely CM, Kwieciszewski B, Tan SL, Dossett M, Tang NM, Korth MJ, Polyak SJ, Gretch DR, Katze MG.

Mol Cell Biol. 1998 Sep;18(9):5208-18.

5.

Repression of the PKR protein kinase by the hepatitis C virus NS5A protein: a potential mechanism of interferon resistance.

Gale MJ Jr, Korth MJ, Katze MG.

Clin Diagn Virol. 1998 Jul 15;10(2-3):157-62. Review.

PMID:
9741641
6.

Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein.

Gale MJ Jr, Korth MJ, Tang NM, Tan SL, Hopkins DA, Dever TE, Polyak SJ, Gretch DR, Katze MG.

Virology. 1997 Apr 14;230(2):217-27.

7.

Effects of mutation in hepatitis C virus nonstructural protein 5A on interferon resistance mediated by inhibition of PKR kinase activity in mammalian cells.

Noguchi T, Satoh S, Noshi T, Hatada E, Fukuda R, Kawai A, Ikeda S, Hijikata M, Shimotohno K.

Microbiol Immunol. 2001;45(12):829-40. Erratum in: Microbiol Immunol. 2002;46(4):305.

8.

The NS5A protein of hepatitis C virus partially inhibits the antiviral activity of interferon.

Song J, Fujii M, Wang F, Itoh M, Hotta H.

J Gen Virol. 1999 Apr;80 ( Pt 4):879-86.

PMID:
10211956
9.

Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response.

Polyak SJ, Khabar KS, Paschal DM, Ezelle HJ, Duverlie G, Barber GN, Levy DE, Mukaida N, Gretch DR.

J Virol. 2001 Jul;75(13):6095-106.

10.

Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication.

Polyak SJ, Paschal DM, McArdle S, Gale MJ Jr, Moradpour D, Gretch DR.

Hepatology. 1999 Apr;29(4):1262-71.

PMID:
10094974
11.

The non-structural 5A protein of hepatitis C virus exhibits genotypic differences in interferon antagonism.

Tsai YH, Kuang WF, Lu TY, Kao JH, Lai MY, Liu CJ, Chen PJ, Hwang LH.

J Hepatol. 2008 Dec;49(6):899-907. doi: 10.1016/j.jhep.2008.06.030. Epub 2008 Sep 16.

PMID:
18842320
12.

Mutations in the NS5A and E2-PePHD region of hepatitis C virus type 1b and correlation with the response to combination therapy with interferon and ribavirin.

Hung CH, Lee CM, Lu SN, Lee JF, Wang JH, Tung HD, Chen TM, Hu TH, Chen WJ, Changchien CS.

J Viral Hepat. 2003 Mar;10(2):87-94.

PMID:
12614464
13.
14.

Mutations in the E2-PePHD and NS5A region of hepatitis C virus type 1 and the dynamics of hepatitis C viremia decline during interferon alfa treatment.

Berg T, Mas Marques A, Höhne M, Wiedenmann B, Hopf U, Schreier E.

Hepatology. 2000 Dec;32(6):1386-95.

PMID:
11093746
15.

NS5A(ISDR-V3) region genetic variability of Tunisian HCV-1b strains: Correlation with the response to the combined interferon/ribavirin therapy.

Bouzgarrou N, Hassen E, Mahfoudh W, Gabbouj S, Schvoerer E, Ben Yahia A, Ben Mami N, Triki H, Chouchane L.

J Med Virol. 2009 Dec;81(12):2021-8. doi: 10.1002/jmv.21641.

PMID:
19856481
16.

Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesis.

François C, Duverlie G, Rebouillat D, Khorsi H, Castelain S, Blum HE, Gatignol A, Wychowski C, Moradpour D, Meurs EF.

J Virol. 2000 Jun;74(12):5587-96.

17.

The nonstructural 5A protein of hepatitis C virus genotype 1b does not contain an interferon sensitivity-determining region.

Brillet R, Penin F, Hezode C, Chouteau P, Dhumeaux D, Pawlotsky JM.

J Infect Dis. 2007 Feb 1;195(3):432-41. Epub 2006 Dec 18.

PMID:
17205483
18.

Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A.

Hiet MS, Bauhofer O, Zayas M, Roth H, Tanaka Y, Schirmacher P, Willemsen J, Grünvogel O, Bender S, Binder M, Lohmann V, Lotteau V, Ruggieri A, Bartenschlager R.

J Hepatol. 2015 Oct;63(4):829-37. doi: 10.1016/j.jhep.2015.04.015. Epub 2015 Apr 20.

19.

Variability of the nonstructural 5A protein of hepatitis C virus type 3a isolates and relation to interferon sensitivity.

Castelain S, Khorsi H, Roussel J, François C, Jaillon O, Capron D, Penin F, Wychowski C, Meurs E, Duverlie G; Agence Nationale de Recherche sur le SIDA AC11 Group.

J Infect Dis. 2002 Mar 1;185(5):573-83. Epub 2002 Feb 14.

PMID:
11865413
20.

GB virus type C NS5A sequence polymorphisms: association with interferon susceptibility and inhibition of PKR-mediated eIF2alpha phosphorylation.

Xiang J, Martinez-Smith C, Gale M Jr, Chang Q, Labrecque DR, Schmidt WN, Stapleton JT.

J Interferon Cytokine Res. 2005 May;25(5):261-70.

PMID:
15871663

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