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Items: 1 to 20 of 224

1.

The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade.

Street A, Macdonald A, Crowder K, Harris M.

J Biol Chem. 2004 Mar 26;279(13):12232-41. Epub 2004 Jan 5.

2.

HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.

Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD.

Oncogene. 2002 Jul 18;21(31):4801-11.

3.

The hepatitis C virus non-structural NS5A protein inhibits activating protein-1 function by perturbing ras-ERK pathway signaling.

Macdonald A, Crowder K, Street A, McCormick C, Saksela K, Harris M.

J Biol Chem. 2003 May 16;278(20):17775-84. Epub 2003 Mar 5.

4.

Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity.

Li Y, Anderson DH, Liu Q, Zhou Y.

J Biol Chem. 2008 Aug 22;283(34):23397-409. doi: 10.1074/jbc.M802737200. Epub 2008 Jun 5.

5.

Cleavage of hepatitis C virus nonstructural protein 5A by a caspase-like protease(s) in mammalian cells.

Satoh S, Hirota M, Noguchi T, Hijikata M, Handa H, Shimotohno K.

Virology. 2000 May 10;270(2):476-87.

6.

Characterization of a HCV NS5A protein derived from a patient with hepatoma.

Yeh CT, Chang MH, Shyu WC, Chang ML, Yang PY, Tsao ML, Lai HY.

Biochem Biophys Res Commun. 2005 Feb 11;327(2):516-22.

PMID:
15629144
7.

Association of amino acid variations in the NS5A and E2-PePHD region of hepatitis C virus 1b with hepatocellular carcinoma.

Hung CH, Chen CH, Lee CM, Wu CM, Hu TH, Wang JH, Yen YH, Lu SN.

J Viral Hepat. 2008 Jan;15(1):58-65.

PMID:
18088246
8.

The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis.

Erdtmann L, Franck N, Lerat H, Le Seyec J, Gilot D, Cannie I, Gripon P, Hibner U, Guguen-Guillouzo C.

J Biol Chem. 2003 May 16;278(20):18256-64. Epub 2003 Feb 20.

9.

Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B.

Hamamoto I, Nishimura Y, Okamoto T, Aizaki H, Liu M, Mori Y, Abe T, Suzuki T, Lai MM, Miyamura T, Moriishi K, Matsuura Y.

J Virol. 2005 Nov;79(21):13473-82.

10.

Hepatitis C virus NS5A: tales of a promiscuous protein.

Macdonald A, Harris M.

J Gen Virol. 2004 Sep;85(Pt 9):2485-502. Review.

PMID:
15302943
11.

The oncogenic role of NS5A of hepatitis C virus is mediated by up-regulation of survivin gene expression in the hepatocellular cell through p53 and NF-κB pathways.

Jiang YF, He B, Li NP, Ma J, Gong GZ, Zhang M.

Cell Biol Int. 2011 Dec;35(12):1225-32. doi: 10.1042/CBI20110102.

PMID:
21612579
12.

Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly.

Appel N, Zayas M, Miller S, Krijnse-Locker J, Schaller T, Friebe P, Kallis S, Engel U, Bartenschlager R.

PLoS Pathog. 2008 Mar 28;4(3):e1000035. doi: 10.1371/journal.ppat.1000035.

13.

[Expression of HCV NS5A gene in HepG2 cell and the effect of the NS5A expression on PI3K in vitro].

Hu XF, Deng XZ, Diao ZY, Zhang Y, Zhou ZA, Liu Y.

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007 Dec;23(12):1133-5. Chinese.

PMID:
18062885
14.

Induction of a unique gene expression profile in primary human hepatocytes by hepatitis C virus core, NS3 and NS5A proteins.

Budhu A, Chen Y, Kim JW, Forgues M, Valerie K, Harris CC, Wang XW.

Carcinogenesis. 2007 Jul;28(7):1552-60. Epub 2007 Apr 2.

PMID:
17404395
16.

Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding protein.

Huang L, Hwang J, Sharma SD, Hargittai MR, Chen Y, Arnold JJ, Raney KD, Cameron CE.

J Biol Chem. 2005 Oct 28;280(43):36417-28. Epub 2005 Aug 25.

17.

Hepatitis C virus NS5A binds to the mRNA cap-binding eukaryotic translation initiation 4F (eIF4F) complex and up-regulates host translation initiation machinery through eIF4E-binding protein 1 inactivation.

George A, Panda S, Kudmulwar D, Chhatbar SP, Nayak SC, Krishnan HH.

J Biol Chem. 2012 Feb 10;287(7):5042-58. doi: 10.1074/jbc.M111.308916. Epub 2011 Dec 19.

18.

Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus.

Ahn J, Chung KS, Kim DU, Won M, Kim L, Kim KS, Nam M, Choi SJ, Kim HC, Yoon M, Chae SK, Hoe KL.

J Biochem Mol Biol. 2004 Nov 30;37(6):741-8.

PMID:
15607035
19.

Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines.

Abe T, Kaname Y, Hamamoto I, Tsuda Y, Wen X, Taguwa S, Moriishi K, Takeuchi O, Kawai T, Kanto T, Hayashi N, Akira S, Matsuura Y.

J Virol. 2007 Sep;81(17):8953-66. Epub 2007 Jun 13.

20.

Hepatitis C virus nonstructural protein-5A activates sterol regulatory element-binding protein-1c through transcription factor Sp1.

Xiang Z, Qiao L, Zhou Y, Babiuk LA, Liu Q.

Biochem Biophys Res Commun. 2010 Nov 19;402(3):549-53. doi: 10.1016/j.bbrc.2010.10.081. Epub 2010 Oct 29.

PMID:
20971080

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