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Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein.

Taylor DR, Shi ST, Romano PR, Barber GN, Lai MM.

Science. 1999 Jul 2;285(5424):107-10.


Regulation of mRNA translation and cellular signaling by hepatitis C virus nonstructural protein NS5A.

He Y, Tan SL, Tareen SU, Vijaysri S, Langland JO, Jacobs BL, Katze MG.

J Virol. 2001 Jun;75(11):5090-8.


p58IPK is an inhibitor of the eIF2╬▒ kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.

Roobol A, Roobol J, Bastide A, Knight JR, Willis AE, Smales CM.

Biochem J. 2015 Jan 15;465(2):213-25. doi: 10.1042/BJ20140852.


The PERK Arm of the Unfolded Protein Response Negatively Regulates Transmissible Gastroenteritis Virus Replication by Suppressing Protein Translation and Promoting Type I Interferon Production.

Xue M, Fu F, Ma Y, Zhang X, Li L, Feng L, Liu P.

J Virol. 2018 Jul 17;92(15). pii: e00431-18. doi: 10.1128/JVI.00431-18. Print 2018 Aug 1.


Regulation of de novo translation of host cells by manipulation of PERK/PKR and GADD34-PP1 activity during Newcastle disease virus infection.

Liao Y, Gu F, Mao X, Niu Q, Wang H, Sun Y, Song C, Qiu X, Tan L, Ding C.

J Gen Virol. 2016 Apr;97(4):867-79. doi: 10.1099/jgv.0.000426. Epub 2016 Feb 11.


Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.

Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromilas A, Wouters BG.

Mol Cell Biol. 2002 Nov;22(21):7405-16.


Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase.

Harding HP, Zhang Y, Ron D.

Nature. 1999 Jan 21;397(6716):271-4. Erratum in: Nature 1999 Mar 4;398(6722):90.


Analysis of the PKR-eIF2alpha phosphorylation homology domain (PePHD) of hepatitis C virus genotype 1 in HIV-coinfected patients by ultra-deep pyrosequencing and its relationship to responses to pegylated interferon-ribavirin treatment.

Bolcic F, Sede M, Moretti F, Westergaard G, Vazquez M, Laufer N, Quarleri J.

Arch Virol. 2012 Apr;157(4):703-11. doi: 10.1007/s00705-012-1230-1. Epub 2012 Jan 22.


PERK Signal-Modulated Protein Translation Promotes the Survivability of Dengue 2 Virus-Infected Mosquito Cells and Extends Viral Replication.

Hou JN, Chen TH, Chiang YH, Peng JY, Yang TH, Cheng CC, Sofiyatun E, Chiu CH, Chiang-Ni C, Chen WJ.

Viruses. 2017 Sep 20;9(9). pii: E262. doi: 10.3390/v9090262.


Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK.

Yan W, Frank CL, Korth MJ, Sopher BL, Novoa I, Ron D, Katze MG.

Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15920-5. Epub 2002 Nov 22.


Inhibition of PKR protects against tunicamycin-induced apoptosis in neuroblastoma cells.

Vaughn LS, Snee B, Patel RC.

Gene. 2014 Feb 15;536(1):90-6. doi: 10.1016/j.gene.2013.11.074. Epub 2013 Dec 14.


Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesis.

Fran├žois C, Duverlie G, Rebouillat D, Khorsi H, Castelain S, Blum HE, Gatignol A, Wychowski C, Moradpour D, Meurs EF.

J Virol. 2000 Jun;74(12):5587-96.


TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress.

Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A.

PLoS One. 2014 Nov 13;9(11):e112761. doi: 10.1371/journal.pone.0112761. eCollection 2014.


PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2alpha phosphorylation.

Raven JF, Baltzis D, Wang S, Mounir Z, Papadakis AI, Gao HQ, Koromilas AE.

J Biol Chem. 2008 Feb 8;283(6):3097-108. Epub 2007 Dec 6.


Sequence analysis of PePHD within HCV E2 region and correlation with resistance of interferon therapy in Japanese patients infected with HCV genotypes 2a and 2b.

Saito T, Ito T, Ishiko H, Yonaha M, Morikawa K, Miyokawa A, Mitamura K.

Am J Gastroenterol. 2003 Jun;98(6):1377-83.


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