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Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase.

He Y, Nakao H, Tan SL, Polyak SJ, Neddermann P, Vijaysri S, Jacobs BL, Katze MG.

J Virol. 2002 Sep;76(18):9207-17.


The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.

Pelicci G, Troglio F, Bodini A, Melillo RM, Pettirossi V, Coda L, De Giuseppe A, Santoro M, Pelicci PG.

Mol Cell Biol. 2002 Oct;22(20):7351-63.


The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair.

Fan S, Ma YX, Gao M, Yuan RQ, Meng Q, Goldberg ID, Rosen EM.

Mol Cell Biol. 2001 Aug;21(15):4968-84.


ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase.

Yu CF, Liu ZX, Cantley LG.

J Biol Chem. 2002 May 31;277(22):19382-8. Epub 2002 Mar 14.


Activated STAT5 proteins induce activation of the PI 3-kinase/Akt and Ras/MAPK pathways via the Gab2 scaffolding adapter.

Nyga R, Pecquet C, Harir N, Gu H, Dhennin-Duthille I, R├ęgnier A, Gouilleux-Gruart V, Lassoued K, Gouilleux F.

Biochem J. 2005 Aug 15;390(Pt 1):359-66.


Role of the Grb2-associated binder 1/SHP-2 interaction in cell growth and transformation.

Holgado-Madruga M, Wong AJ.

Cancer Res. 2004 Mar 15;64(6):2007-15.


1Hepatitis C virus NS5A protein modulates c-Jun N-terminal kinase through interaction with tumor necrosis factor receptor-associated factor 2.

Park KJ, Choi SH, Choi DH, Park JM, Yie SW, Lee SY, Hwang SB.

J Biol Chem. 2003 Aug 15;278(33):30711-8. Epub 2003 Jun 7.


Morphine induces desensitization of insulin receptor signaling.

Li Y, Eitan S, Wu J, Evans CJ, Kieffer B, Sun X, Polakiewicz RD.

Mol Cell Biol. 2003 Sep;23(17):6255-66.


Biochemical and biological responses induced by coupling of Gab1 to phosphatidylinositol 3-kinase in RET-expressing cells.

Maeda K, Murakami H, Yoshida R, Ichihara M, Abe A, Hirai M, Murohara T, Takahashi M.

Biochem Biophys Res Commun. 2004 Oct 8;323(1):345-54.


Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins.

Ong SH, Hadari YR, Gotoh N, Guy GR, Schlessinger J, Lax I.

Proc Natl Acad Sci U S A. 2001 May 22;98(11):6074-9. Epub 2001 May 15.


Insulin-like growth factor-I stimulates Shc-dependent phosphatidylinositol 3-kinase activation via Grb2-associated p85 in vascular smooth muscle cells.

Radhakrishnan Y, Maile LA, Ling Y, Graves LM, Clemmons DR.

J Biol Chem. 2008 Jun 13;283(24):16320-31. doi: 10.1074/jbc.M801687200. Epub 2008 Apr 16.


Regulation of hepatitis B virus replication by the phosphatidylinositol 3-kinase-akt signal transduction pathway.

Guo H, Zhou T, Jiang D, Cuconati A, Xiao GH, Block TM, Guo JT.

J Virol. 2007 Sep;81(18):10072-80. Epub 2007 Jul 3.


Phosphorylation of the Grb2- and phosphatidylinositol 3-kinase p85-binding p36/38 by Syk in Lck-negative T cells.

von Willebrand M, Williams S, Tailor P, Mustelin T.

Cell Signal. 1998 Jun;10(6):407-13.


Hepatitis C Virus Nonstructural 5A Protein Interacts with Abelson Interactor 1 and Modulates Epidermal Growth Factor-mediated MEK/ERK Signaling Pathway.

Huynh VT, Lim YS, Tran SC, Pham TM, Nguyen LN, Hwang SB.

J Biol Chem. 2016 Oct 21;291(43):22607-22617. Epub 2016 Aug 22.


Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2.

Zhang SQ, Tsiaras WG, Araki T, Wen G, Minichiello L, Klein R, Neel BG.

Mol Cell Biol. 2002 Jun;22(12):4062-72.


Identification of major ERK-related phosphorylation sites in Gab1.

Lehr S, Kotzka J, Avci H, Sickmann A, Meyer HE, Herkner A, Muller-Wieland D.

Biochemistry. 2004 Sep 28;43(38):12133-40.


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