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Items: 1 to 20 of 184

1.

Identification of signal peptide peptidase, a presenilin-type aspartic protease.

Weihofen A, Binns K, Lemberg MK, Ashman K, Martoglio B.

Science. 2002 Jun 21;296(5576):2215-8.

2.

Biochemistry. Intramembrane proteases--mixing oil and water.

Wolfe MS, Selkoe DJ.

Science. 2002 Jun 21;296(5576):2156-7. No abstract available.

PMID:
12077393
3.

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3.

Krawitz P, Haffner C, Fluhrer R, Steiner H, Schmid B, Haass C.

J Biol Chem. 2005 Nov 25;280(47):39515-23. Epub 2005 Jul 5.

4.
5.

Intramembrane proteolysis by presenilin and presenilin-like proteases.

Xia W, Wolfe MS.

J Cell Sci. 2003 Jul 15;116(Pt 14):2839-44. Review.

6.

C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.

Wang J, Beher D, Nyborg AC, Shearman MS, Golde TE, Goate A.

J Neurochem. 2006 Jan;96(1):218-27. Epub 2005 Nov 23.

7.

Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors.

Weihofen A, Lemberg MK, Friedmann E, Rueeger H, Schmitz A, Paganetti P, Rovelli G, Martoglio B.

J Biol Chem. 2003 May 9;278(19):16528-33. Epub 2003 Mar 5.

8.

Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor.

Nyborg AC, Kornilova AY, Jansen K, Ladd TB, Wolfe MS, Golde TE.

J Biol Chem. 2004 Apr 9;279(15):15153-60. Epub 2004 Jan 2.

9.

A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex.

Lee SF, Shah S, Yu C, Wigley WC, Li H, Lim M, Pedersen K, Han W, Thomas P, Lundkvist J, Hao YH, Yu G.

J Biol Chem. 2004 Feb 6;279(6):4144-52. Epub 2003 Nov 19.

10.

Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals.

Dev KK, Chatterjee S, Osinde M, Stauffer D, Morgan H, Kobialko M, Dengler U, Rueeger H, Martoglio B, Rovelli G.

Eur J Pharmacol. 2006 Jul 1;540(1-3):10-7. Epub 2006 Apr 15.

PMID:
16697367
11.

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.

Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, Edbauer D, Walter J, Steiner H, Haass C.

J Biol Chem. 2002 Nov 22;277(47):44754-9. Epub 2002 Sep 9.

12.

Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs.

Sato T, Nyborg AC, Iwata N, Diehl TS, Saido TC, Golde TE, Wolfe MS.

Biochemistry. 2006 Jul 18;45(28):8649-56.

PMID:
16834339
13.

Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs.

Martoglio B, Golde TE.

Hum Mol Genet. 2003 Oct 15;12 Spec No 2:R201-6. Epub 2003 Sep 9. Review.

PMID:
12966028
14.

Novel class of polytopic proteins with domains associated with putative protease activity.

Grigorenko AP, Moliaka YK, Korovaitseva GI, Rogaev EI.

Biochemistry (Mosc). 2002 Jul;67(7):826-35.

16.

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases.

Steiner H, Kostka M, Romig H, Basset G, Pesold B, Hardy J, Capell A, Meyn L, Grim ML, Baumeister R, Fechteler K, Haass C.

Nat Cell Biol. 2000 Nov;2(11):848-51.

PMID:
11056541
17.

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins.

Friedmann E, Lemberg MK, Weihofen A, Dev KK, Dengler U, Rovelli G, Martoglio B.

J Biol Chem. 2004 Dec 3;279(49):50790-8. Epub 2004 Sep 21.

18.

RIPped out by presenilin-dependent gamma-secretase.

Medina M, Dotti CG.

Cell Signal. 2003 Sep;15(9):829-41. Review.

PMID:
12834808
19.

Gamma-secretase--intramembrane protease with a complex.

Wolfe MS.

Sci Aging Knowledge Environ. 2003 Mar 19;2003(11):PE7.

PMID:
12844518
20.

Expression of the presenilin-like signal peptide peptidase (SPP) in mouse adult brain and during development.

Urny J, Hermans-Borgmeyer I, Gercken G, Schaller HC.

Gene Expr Patterns. 2003 Oct;3(5):685-91.

PMID:
12972007

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