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Items: 1 to 20 of 166


CD27 is required for generation and long-term maintenance of T cell immunity.

Hendriks J, Gravestein LA, Tesselaar K, van Lier RA, Schumacher TN, Borst J.

Nat Immunol. 2000 Nov;1(5):433-40.


During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion.

Hendriks J, Xiao Y, Rossen JW, van der Sluijs KF, Sugamura K, Ishii N, Borst J.

J Immunol. 2005 Aug 1;175(3):1665-76.


4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy.

Cannons JL, Lau P, Ghumman B, DeBenedette MA, Yagita H, Okumura K, Watts TH.

J Immunol. 2001 Aug 1;167(3):1313-24.


The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants.

van Gisbergen KP, Klarenbeek PL, Kragten NA, Unger PP, Nieuwenhuis MB, Wensveen FM, ten Brinke A, Tak PP, Eldering E, Nolte MA, van Lier RA.

Immunity. 2011 Jul 22;35(1):97-108. doi: 10.1016/j.immuni.2011.04.020. Epub 2011 Jul 14.


The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion.

Gramaglia I, Jember A, Pippig SD, Weinberg AD, Killeen N, Croft M.

J Immunol. 2000 Sep 15;165(6):3043-50.


LIGHT is dispensable for CD4+ and CD8+ T cell and antibody responses to influenza A virus in mice.

Sedgmen BJ, Dawicki W, Gommerman JL, Pfeffer K, Watts TH.

Int Immunol. 2006 May;18(5):797-806. Epub 2006 Mar 28.


CD27 instructs CD4+ T cells to provide help for the memory CD8+ T cell response after protein immunization.

Xiao Y, Peperzak V, Keller AM, Borst J.

J Immunol. 2008 Jul 15;181(2):1071-82.


CD4+ T cell help improves CD8+ T cell memory by retained CD27 expression.

Matter MS, Claus C, Ochsenbein AF.

Eur J Immunol. 2008 Jul;38(7):1847-56. doi: 10.1002/eji.200737824.


A switch in costimulation from CD28 to 4-1BB during primary versus secondary CD8 T cell response to influenza in vivo.

Bertram EM, Dawicki W, Sedgmen B, Bramson JL, Lynch DH, Watts TH.

J Immunol. 2004 Jan 15;172(2):981-8.


LFA-1 defect-induced effector/memory CD8+ T cell apoptosis is mediated via Bcl-2/Caspase pathways and associated with downregulation of CD27 and IL-15R.

Ye Z, Shi M, Xu S, Xiang J.

Mol Immunol. 2010 Aug;47(14):2411-21. doi: 10.1016/j.molimm.2010.02.005. Epub 2010 May 31.


CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo.

Yamada A, Salama AD, Sho M, Najafian N, Ito T, Forman JP, Kewalramani R, Sandner S, Harada H, Clarkson MR, Mandelbrot DA, Sharpe AH, Oshima H, Yagita H, Chalasani G, Lakkis FG, Auchincloss H Jr, Sayegh MH.

J Immunol. 2005 Feb 1;174(3):1357-64.


Quantitative analysis of the influenza virus-specific CD4+ T cell memory in the absence of B cells and Ig.

Topham DJ, Tripp RA, Hamilton-Easton AM, Sarawar SR, Doherty PC.

J Immunol. 1996 Oct 1;157(7):2947-52.


TNF receptor type 2 (p75) functions as a costimulator for antigen-driven T cell responses in vivo.

Kim EY, Priatel JJ, Teh SJ, Teh HS.

J Immunol. 2006 Jan 15;176(2):1026-35.


4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses.

Dawicki W, Bertram EM, Sharpe AH, Watts TH.

J Immunol. 2004 Nov 15;173(10):5944-51.


Requirement for CD70 in CD4+ Th cell-dependent and innate receptor-mediated CD8+ T cell priming.

Taraban VY, Rowley TF, Tough DF, Al-Shamkhani A.

J Immunol. 2006 Sep 1;177(5):2969-75.


OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection.

Kopf M, Ruedl C, Schmitz N, Gallimore A, Lefrang K, Ecabert B, Odermatt B, Bachmann MF.

Immunity. 1999 Dec;11(6):699-708.


The Pim kinase pathway contributes to survival signaling in primed CD8+ T cells upon CD27 costimulation.

Peperzak V, Veraar EA, Keller AM, Xiao Y, Borst J.

J Immunol. 2010 Dec 1;185(11):6670-8. doi: 10.4049/jimmunol.1000159. Epub 2010 Nov 3.


Expression of costimulatory ligand CD70 on steady-state dendritic cells breaks CD8+ T cell tolerance and permits effective immunity.

Keller AM, Schildknecht A, Xiao Y, van den Broek M, Borst J.

Immunity. 2008 Dec 19;29(6):934-46. doi: 10.1016/j.immuni.2008.10.009. Epub 2008 Dec 8.


Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells.

Schluns KS, Williams K, Ma A, Zheng XX, Lefran├žois L.

J Immunol. 2002 May 15;168(10):4827-31.

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