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Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.

Schaeffer EM, Debnath J, Yap G, McVicar D, Liao XC, Littman DR, Sher A, Varmus HE, Lenardo MJ, Schwartzberg PL.

Science. 1999 Apr 23;284(5414):638-41.


Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell.

Yablonski D, Kuhne MR, Kadlecek T, Weiss A.

Science. 1998 Jul 17;281(5375):413-6.


Positive feedback regulation of PLCgamma1/Ca(2+) signaling by PKCtheta in restimulated T cells via a Tec kinase-dependent pathway.

Altman A, Kaminski S, Busuttil V, Droin N, Hu J, Tadevosyan Y, Hipskind RA, Villalba M.

Eur J Immunol. 2004 Jul;34(7):2001-11.


Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help.

Atherly LO, Brehm MA, Welsh RM, Berg LJ.

J Immunol. 2006 Feb 1;176(3):1571-81. Erratum in: J Immunol. 2006 Mar 15;176(6):3842.


The role of Tec protein-tyrosine kinase in T cell signaling.

Yang WC, Ghiotto M, Barbarat B, Olive D.

J Biol Chem. 1999 Jan 8;274(2):607-17.


Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways.

Gajewski TF, Qian D, Fields P, Fitch FW.

Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):38-42.


Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade.

Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ.

J Biol Chem. 2000 Jan 21;275(3):2219-30.


The role of Tec family kinases in T cell development and function.

Lucas JA, Miller AT, Atherly LO, Berg LJ.

Immunol Rev. 2003 Feb;191:119-38. Review.


The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells.

Atherly LO, Lucas JA, Felices M, Yin CC, Reiner SL, Berg LJ.

Immunity. 2006 Jul;25(1):79-91.


CD3-zeta surface expression is required for CD4-p56lck-mediated upregulation of T cell antigen receptor-CD3 signaling in T cells.

Sancho J, Ledbetter JA, Choi MS, Kanner SB, Deans JP, Terhorst C.

J Biol Chem. 1992 Apr 15;267(11):7871-9.


Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk.

Chamorro M, Czar MJ, Debnath J, Cheng G, Lenardo MJ, Varmus HE, Schwartzberg PL.

BMC Immunol. 2001;2:3. Epub 2001 May 8.


Subtle defects in pre-TCR signaling in the absence of the Tec kinase Itk.

Lucas JA, Felices M, Evans JW, Berg LJ.

J Immunol. 2007 Dec 1;179(11):7561-7.


Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

June CH, Fletcher MC, Ledbetter JA, Schieven GL, Siegel JN, Phillips AF, Samelson LE.

Proc Natl Acad Sci U S A. 1990 Oct;87(19):7722-6.


A LAT mutation that inhibits T cell development yet induces lymphoproliferation.

Sommers CL, Park CS, Lee J, Feng C, Fuller CL, Grinberg A, Hildebrand JA, LacanĂ¡ E, Menon RK, Shores EW, Samelson LE, Love PE.

Science. 2002 Jun 14;296(5575):2040-3.

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