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Items: 1 to 20 of 27

1.

CTRC gene polymorphism (p.G60=; c.180 C > T) in acute pancreatitis.

Koziel D, Gluszek S, Kowalik A, Chlopek M.

BMC Gastroenterol. 2017 Jan 17;17(1):13. doi: 10.1186/s12876-016-0566-5.

2.

PRSS1, SPINK1, CFTR, and CTRC Pathogenic Variants in Korean Patients With Idiopathic Pancreatitis.

Cho SM, Shin S, Lee KA.

Ann Lab Med. 2016 Nov;36(6):555-60. doi: 10.3343/alm.2016.36.6.555.

3.

Tighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary Pancreatitis.

Jancsó Z, Sahin-Tóth M.

J Biol Chem. 2016 Jun 17;291(25):12897-905. doi: 10.1074/jbc.M116.725374. Epub 2016 Apr 18.

4.

Report of 2 CTRC Intronic Mutations Associated With Acute or Chronic Pancreatitis and Delineation of Their Pathogenic Molecular Mechanisms.

Masson E, Chen JM, Férec C.

Pancreas. 2015 Aug;44(6):999-1001. doi: 10.1097/MPA.0000000000000359. No abstract available.

PMID:
26166474
5.

Genetic mutations in SPINK1, CFTR, CTRC genes in acute pancreatitis.

Koziel D, Gluszek S, Kowalik A, Chlopek M, Pieciak L.

BMC Gastroenterol. 2015 Jun 23;15:70. doi: 10.1186/s12876-015-0302-6.

6.

ER stress-associated CTRC mutants decrease stimulated pancreatic zymogen secretion through SIRT2-mediated microtubule dysregulation.

Binker MG, Richards D, Gaisano HY, Cosen-Binker LI.

Biochem Biophys Res Commun. 2015 Jul 31;463(3):329-35. doi: 10.1016/j.bbrc.2015.05.064. Epub 2015 May 28.

PMID:
26022124
7.

Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.

Szabó A, Ludwig M, Hegyi E, Szépeová R, Witt H, Sahin-Tóth M.

J Biol Chem. 2015 Jul 10;290(28):17282-92. doi: 10.1074/jbc.M114.618439. Epub 2015 May 26.

8.

Genetic and electrophysiological characteristics of recurrent acute pancreatitis.

Werlin S, Konikoff FM, Halpern Z, Barkay O, Yerushalmi B, Broide E, Santo E, Shamir R, Shaoul R, Shteyer E, Yaakov Y, Cohen M, Kerem E, Ruszniewski P, Masson E, Ferec C, Wilschanski M.

J Pediatr Gastroenterol Nutr. 2015 May;60(5):675-9. doi: 10.1097/MPG.0000000000000623.

PMID:
25383785
9.

CFTR, SPINK1, PRSS1, and CTRC mutations are not associated with pancreatic cancer in German patients.

Schubert S, Traub F, Brakensiek K, von Kopylow K, Marohn B, Maelzer M, Gaedcke J, Kreipe H, Stuhrmann M.

Pancreas. 2014 Oct;43(7):1078-82. doi: 10.1097/MPA.0000000000000166.

PMID:
25003218
10.

A conservative assessment of the major genetic causes of idiopathic chronic pancreatitis: data from a comprehensive analysis of PRSS1, SPINK1, CTRC and CFTR genes in 253 young French patients.

Masson E, Chen JM, Audrézet MP, Cooper DN, Férec C.

PLoS One. 2013 Aug 8;8(8):e73522. doi: 10.1371/journal.pone.0073522. eCollection 2013.

11.

Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation.

Batra J, Szabó A, Caulfield TR, Soares AS, Sahin-Tóth M, Radisky ES.

J Biol Chem. 2013 Apr 5;288(14):9848-59. doi: 10.1074/jbc.M113.457382. Epub 2013 Feb 19.

12.

Identification of novel missense CTRC variants in Japanese patients with chronic pancreatitis.

Masamune A, Nakano E, Kume K, Kakuta Y, Ariga H, Shimosegawa T.

Gut. 2013 Apr;62(4):653-4. doi: 10.1136/gutjnl-2012-303860. Epub 2012 Nov 7. No abstract available.

PMID:
23135764
13.

Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk.

Beer S, Zhou J, Szabó A, Keiles S, Chandak GR, Witt H, Sahin-Tóth M.

Gut. 2013 Nov;62(11):1616-24. doi: 10.1136/gutjnl-2012-303090. Epub 2012 Sep 1.

14.

Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants.

Paliwal S, Bhaskar S, Mani KR, Reddy DN, Rao GV, Singh SP, Thomas V, Chandak GR.

Gut. 2013 Nov;62(11):1602-6. doi: 10.1136/gutjnl-2012-302448. Epub 2012 May 12.

PMID:
22580415
15.

Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin C.

Szabó A, Sahin-Tóth M.

J Biol Chem. 2012 Jun 8;287(24):20701-10. doi: 10.1074/jbc.M112.360065. Epub 2012 Apr 26.

16.

CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated?

Rosendahl J, Landt O, Bernadova J, Kovacs P, Teich N, Bödeker H, Keim V, Ruffert C, Mössner J, Kage A, Stumvoll M, Groneberg D, Krüger R, Luck W, Treiber M, Becker M, Witt H.

Gut. 2013 Apr;62(4):582-92. doi: 10.1136/gutjnl-2011-300645. Epub 2012 Mar 17.

PMID:
22427236
17.

Chymotrypsin C mutations in chronic pancreatitis.

Zhou J, Sahin-Tóth M.

J Gastroenterol Hepatol. 2011 Aug;26(8):1238-46. doi: 10.1111/j.1440-1746.2011.06791.x. Review.

18.

Effect of chymotrypsin C and related proteins on pancreatic cancer cell migration.

Wang H, Sha W, Liu Z, Chi CW.

Acta Biochim Biophys Sin (Shanghai). 2011 May;43(5):362-71. doi: 10.1093/abbs/gmr022. Epub 2011 Apr 2.

PMID:
21460362
19.

Genetic basis of chronic pancreatitis in Asia Pacific region.

Reddy DN, Prasad SS.

J Gastroenterol Hepatol. 2011 Mar;26 Suppl 2:2-5. doi: 10.1111/j.1440-1746.2010.06598.x. Review.

PMID:
21323990
20.

Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2.

Szmola R, Bence M, Carpentieri A, Szabó A, Costello CE, Samuelson J, Sahin-Tóth M.

J Biol Chem. 2011 Jan 21;286(3):1819-27. doi: 10.1074/jbc.M110.187369. Epub 2010 Nov 22.

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