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Items: 18


Six3 in a small population of progenitors at E8.5 is required for neuroretinal specification via regulating cell signaling and survival in mice.

Liu W, Cvekl A.

Dev Biol. 2017 Aug 1;428(1):164-175. doi: 10.1016/j.ydbio.2017.05.026. Epub 2017 Jun 1.


Six3 dosage mediates the pathogenesis of holoprosencephaly.

Geng X, Acosta S, Lagutin O, Gil HJ, Oliver G.

Development. 2016 Dec 1;143(23):4462-4473. Epub 2016 Oct 21.


Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development.

Xie H, Hoffmann HM, Meadows JD, Mayo SL, Trang C, Leming SS, Maruggi C, Davis SW, Larder R, Mellon PL.

Mol Endocrinol. 2015 Jun;29(6):842-55. doi: 10.1210/me.2014-1279. Epub 2015 Apr 27.


Genomic code for Sox2 binding uncovers its regulatory role in Six3 activation in the forebrain.

Lee B, Song H, Rizzoti K, Son Y, Yoon J, Baek K, Jeong Y.

Dev Biol. 2013 Sep 15;381(2):491-501. doi: 10.1016/j.ydbio.2013.06.016. Epub 2013 Jun 19.


Six3 is required for ependymal cell maturation.

Lavado A, Oliver G.

Development. 2011 Dec;138(24):5291-300. doi: 10.1242/dev.067470. Epub 2011 Nov 9.


The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity.

Rapicavoli NA, Poth EM, Zhu H, Blackshaw S.

Neural Dev. 2011 Sep 21;6:32. doi: 10.1186/1749-8104-6-32.


Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate.

Liu W, Lagutin O, Swindell E, Jamrich M, Oliver G.

J Clin Invest. 2010 Oct;120(10):3568-77. doi: 10.1172/JCI43219. Epub 2010 Sep 20.


Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein.

Jeong Y, Leskow FC, El-Jaick K, Roessler E, Muenke M, Yocum A, Dubourg C, Li X, Geng X, Oliver G, Epstein DJ.

Nat Genet. 2008 Nov;40(11):1348-53. doi: 10.1038/ng.230. Epub 2008 Oct 5.


Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development.

Gaston-Massuet C, Andoniadou CL, Signore M, Sajedi E, Bird S, Turner JM, Martinez-Barbera JP.

Dev Biol. 2008 Dec 15;324(2):322-33. doi: 10.1016/j.ydbio.2008.08.008. Epub 2008 Aug 18.


Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly.

Geng X, Speirs C, Lagutin O, Inbal A, Liu W, Solnica-Krezel L, Jeong Y, Epstein DJ, Oliver G.

Dev Cell. 2008 Aug;15(2):236-47. doi: 10.1016/j.devcel.2008.07.003.


Cre recombinase-mediated gene deletion in layer 4 of murine sensory cortical areas.

Liao GY, Xu B.

Genesis. 2008 Jun;46(6):289-93. doi: 10.1002/dvg.20393.


Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon.

Lavado A, Lagutin OV, Oliver G.

Development. 2008 Feb;135(3):441-50. Epub 2007 Dec 19.


Repression of Six3 by a corepressor regulates rhodopsin expression.

Manavathi B, Peng S, Rayala SK, Talukder AH, Wang MH, Wang RA, Balasenthil S, Agarwal N, Frishman LJ, Kumar R.

Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13128-33. Epub 2007 Jul 31.


Six3 activation of Pax6 expression is essential for mammalian lens induction and specification.

Liu W, Lagutin OV, Mende M, Streit A, Oliver G.

EMBO J. 2006 Nov 15;25(22):5383-95. Epub 2006 Oct 26.


Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction.

Purcell P, Oliver G, Mardon G, Donner AL, Maas RL.

Gene Expr Patterns. 2005 Dec;6(1):110-8. Epub 2005 Jul 18.


Comparative analysis of Six 3 and Six 6 distribution in the developing and adult mouse brain.

Conte I, Morcillo J, Bovolenta P.

Dev Dyn. 2005 Nov;234(3):718-25.


Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype.

Goudreau G, Petrou P, Reneker LW, Graw J, Löster J, Gruss P.

Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8719-24. Epub 2002 Jun 18.


Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors.

Zhu CC, Dyer MA, Uchikawa M, Kondoh H, Lagutin OV, Oliver G.

Development. 2002 Jun;129(12):2835-49.

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