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Items: 1 to 20 of 718

1.

Bilirubin Binding to PPARα Inhibits Lipid Accumulation.

Stec DE, John K, Trabbic CJ, Luniwal A, Hankins MW, Baum J, Hinds TD Jr.

PLoS One. 2016 Apr 12;11(4):e0153427. doi: 10.1371/journal.pone.0153427. eCollection 2016.

2.

Preferential PPAR-α activation reduces neuroinflammation, and blocks neurodegeneration in vivo.

Esmaeili MA, Yadav S, Gupta RK, Waggoner GR, Deloach A, Calingasan NY, Beal MF, Kiaei M.

Hum Mol Genet. 2016 Jan 15;25(2):317-27. doi: 10.1093/hmg/ddv477. Epub 2015 Nov 24.

PMID:
26604138
3.

Antagonizing Peroxisome Proliferator-Activated Receptor α Activity Selectively Enhances Th1 Immunity in Male Mice.

Zhang MA, Ahn JJ, Zhao FL, Selvanantham T, Mallevaey T, Stock N, Correa L, Clark R, Spaner D, Dunn SE.

J Immunol. 2015 Dec 1;195(11):5189-202. doi: 10.4049/jimmunol.1500449. Epub 2015 Oct 21.

PMID:
26491197
4.

Effects of macrophage-dependent peroxisome proliferator-activated receptor γ signalling on adhesion formation after abdominal surgery in an experimental model.

Hong GS, Schwandt T, Stein K, Schneiker B, Kummer MP, Heneka MT, Kitamura K, Kalff JC, Wehner S.

Br J Surg. 2015 Nov;102(12):1506-16. doi: 10.1002/bjs.9907. Epub 2015 Aug 27.

PMID:
26313905
5.

HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice.

Roy A, Jana M, Kundu M, Corbett GT, Rangaswamy SB, Mishra RK, Luan CH, Gonzalez FJ, Pahan K.

Cell Metab. 2015 Aug 4;22(2):253-65. doi: 10.1016/j.cmet.2015.05.022. Epub 2015 Jun 25.

6.

Ketone Body Therapy Protects From Lipotoxicity and Acute Liver Failure Upon Pparα Deficiency.

Pawlak M, Baugé E, Lalloyer F, Lefebvre P, Staels B.

Mol Endocrinol. 2015 Aug;29(8):1134-43. doi: 10.1210/me.2014-1383. Epub 2015 Jun 18.

PMID:
26087172
7.

PPARδ preserves a high resistance to fatigue in the mouse medial gastrocnemius after spinal cord transection.

Kim JA, Roy RR, Zhong H, Alaynick WA, Embler E, Jang C, Gomez G, Sonoda T, Evans RM, Edgerton VR.

Muscle Nerve. 2016 Feb;53(2):287-96. doi: 10.1002/mus.24723. Epub 2015 Nov 26.

PMID:
26044200
8.

Voluntary exercise protects against ulcerative colitis by up-regulating glucocorticoid-mediated PPAR-γ activity in the colon in mice.

Liu WX, Zhou F, Wang Y, Wang T, Xing JW, Zhang S, Sang LX, Gu SZ, Wang HL.

Acta Physiol (Oxf). 2015 Sep;215(1):24-36. doi: 10.1111/apha.12534. Epub 2015 Jun 12.

PMID:
26031185
9.

Structurally-diverse, PPARγ-activating environmental toxicants induce adipogenesis and suppress osteogenesis in bone marrow mesenchymal stromal cells.

Watt J, Schlezinger JJ.

Toxicology. 2015 May 4;331:66-77. doi: 10.1016/j.tox.2015.03.006. Epub 2015 Mar 14.

10.

Activation of peroxisome proliferator-activated receptor α induces lysosomal biogenesis in brain cells: implications for lysosomal storage disorders.

Ghosh A, Jana M, Modi K, Gonzalez FJ, Sims KB, Berry-Kravis E, Pahan K.

J Biol Chem. 2015 Apr 17;290(16):10309-24. doi: 10.1074/jbc.M114.610659. Epub 2015 Mar 6.

11.

PPARα regulates endothelial progenitor cell maturation and myeloid lineage differentiation through a NADPH oxidase-dependent mechanism in mice.

Vergori L, Lauret E, Gaceb A, Beauvillain C, Andriantsitohaina R, Martinez MC.

Stem Cells. 2015 Apr;33(4):1292-303. doi: 10.1002/stem.1924.

12.

Transcriptomic signatures of peroxisome proliferator-activated receptor α (PPARα) in different mouse liver models identify novel aspects of its biology.

Szalowska E, Tesfay HA, van Hijum SA, Kersten S.

BMC Genomics. 2014 Dec 15;15:1106. doi: 10.1186/1471-2164-15-1106.

13.

Astragalus polysaccharides repress myocardial lipotoxicity in a PPARalpha-dependent manner in vitro and in vivo in mice.

Chen W, Lai Y, Wang L, Xia Y, Chen W, Zhao X, Yu M, Li Y, Zhang Y, Ye H.

J Diabetes Complications. 2015 Mar;29(2):164-75. doi: 10.1016/j.jdiacomp.2014.11.007. Epub 2014 Nov 25.

PMID:
25499591
14.

Icariin is a PPARα activator inducing lipid metabolic gene expression in mice.

Lu YF, Xu YY, Jin F, Wu Q, Shi JS, Liu J.

Molecules. 2014 Nov 6;19(11):18179-91. doi: 10.3390/molecules191118179.

15.

Peroxisome proliferator-activated receptor α protects capillary pericytes in the retina.

Ding L, Cheng R, Hu Y, Takahashi Y, Jenkins AJ, Keech AC, Humphries KM, Gu X, Elliott MH, Xia X, Ma JX.

Am J Pathol. 2014 Oct;184(10):2709-20. doi: 10.1016/j.ajpath.2014.06.021. Epub 2014 Aug 7.

16.

PPARα-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate.

Qi Y, Jiang C, Tanaka N, Krausz KW, Brocker CN, Fang ZZ, Bredell BX, Shah YM, Gonzalez FJ.

Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G564-73. doi: 10.1152/ajpgi.00153.2014. Epub 2014 Jul 17.

17.

The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice.

Pawlak M, Baugé E, Bourguet W, De Bosscher K, Lalloyer F, Tailleux A, Lebherz C, Lefebvre P, Staels B.

Hepatology. 2014 Nov;60(5):1593-606. doi: 10.1002/hep.27297. Epub 2014 Oct 1.

PMID:
24995693
18.

PPARα-independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis.

Liu M, Montgomery MK, Fiveash CE, Osborne B, Cooney GJ, Bell-Anderson K, Turner N.

Sci Rep. 2014 Jul 2;4:5538. doi: 10.1038/srep05538.

19.

Peroxisome proliferator-activated receptor α activation induces hepatic steatosis, suggesting an adverse effect.

Yan F, Wang Q, Xu C, Cao M, Zhou X, Wang T, Yu C, Jing F, Chen W, Gao L, Zhao J.

PLoS One. 2014 Jun 13;9(6):e99245. doi: 10.1371/journal.pone.0099245. eCollection 2014.

20.

Impairments of hepatic gluconeogenesis and ketogenesis in PPARα-deficient neonatal mice.

Cotter DG, Ercal B, d'Avignon DA, Dietzen DJ, Crawford PA.

Am J Physiol Endocrinol Metab. 2014 Jul 15;307(2):E176-85. doi: 10.1152/ajpendo.00087.2014. Epub 2014 May 27.

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