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Items: 1 to 20 of 41


The orphan nuclear receptor LRH-1 promotes breast cancer motility and invasion.

Chand AL, Herridge KA, Thompson EW, Clyne CD.

Endocr Relat Cancer. 2010 Oct 29;17(4):965-75. doi: 10.1677/ERC-10-0179. Print 2010 Dec.


GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response.

Venteclef N, Jakobsson T, Ehrlund A, Damdimopoulos A, Mikkonen L, Ellis E, Nilsson LM, Parini P, Jänne OA, Gustafsson JA, Steffensen KR, Treuter E.

Genes Dev. 2010 Feb 15;24(4):381-95. doi: 10.1101/gad.545110.


The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist.

Kumar N, Solt LA, Conkright JJ, Wang Y, Istrate MA, Busby SA, Garcia-Ordonez RD, Burris TP, Griffin PR.

Mol Pharmacol. 2010 Feb;77(2):228-36. doi: 10.1124/mol.109.060905. Epub 2009 Nov 3.


Bioactivation of the epidermal growth factor receptor inhibitor gefitinib: implications for pulmonary and hepatic toxicities.

Li X, Kamenecka TM, Cameron MD.

Chem Res Toxicol. 2009 Oct;22(10):1736-42. doi: 10.1021/tx900256y.


Characterization of dasatinib and its structural analogs as CYP3A4 mechanism-based inactivators and the proposed bioactivation pathways.

Li X, He Y, Ruiz CH, Koenig M, Cameron MD, Vojkovsky T.

Drug Metab Dispos. 2009 Jun;37(6):1242-50. doi: 10.1124/dmd.108.025932. Epub 2009 Mar 12. Erratum in: Drug Metab Dispos. 2009 Oct;37(10):2118. Vojkovsky, Tomas [added].


Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening.

Madoux F, Li X, Chase P, Zastrow G, Cameron MD, Conkright JJ, Griffin PR, Thacher S, Hodder P.

Mol Pharmacol. 2008 Jun;73(6):1776-84. doi: 10.1124/mol.108.045963. Epub 2008 Mar 11.


Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1.

Whitby RJ, Dixon S, Maloney PR, Delerive P, Goodwin BJ, Parks DJ, Willson TM.

J Med Chem. 2006 Nov 16;49(23):6652-5.


Liver receptor homolog 1 is a negative regulator of the hepatic acute-phase response.

Venteclef N, Smith JC, Goodwin B, Delerive P.

Mol Cell Biol. 2006 Sep;26(18):6799-807.


Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity.

Solomon IH, Hager JM, Safi R, McDonnell DP, Redinbo MR, Ortlund EA.

J Mol Biol. 2005 Dec 16;354(5):1091-102. Epub 2005 Oct 27.


Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner.

Li Y, Choi M, Suino K, Kovach A, Daugherty J, Kliewer SA, Xu HE.

Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9505-10. Epub 2005 Jun 23.


The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1.

Wang W, Zhang C, Marimuthu A, Krupka HI, Tabrizizad M, Shelloe R, Mehra U, Eng K, Nguyen H, Settachatgul C, Powell B, Milburn MV, West BL.

Proc Natl Acad Sci U S A. 2005 May 24;102(21):7505-10. Epub 2005 May 16.


Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1.

Li Y, Choi M, Cavey G, Daugherty J, Suino K, Kovach A, Bingham NC, Kliewer SA, Xu HE.

Mol Cell. 2005 Feb 18;17(4):491-502.


Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.

Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA.

Cell. 2005 Feb 11;120(3):343-55.


Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation.

Schoonjans K, Dubuquoy L, Mebis J, Fayard E, Wendling O, Haby C, Geboes K, Auwerx J.

Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2058-62. Epub 2005 Jan 31.


Identification of liver receptor homolog-1 as a novel regulator of apolipoprotein AI gene transcription.

Delerive P, Galardi CM, Bisi JE, Nicodeme E, Goodwin B.

Mol Endocrinol. 2004 Oct;18(10):2378-87. Epub 2004 Jun 24.


LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis.

Fayard E, Auwerx J, Schoonjans K.

Trends Cell Biol. 2004 May;14(5):250-60. Review.


Regulation of aromatase expression by the nuclear receptor LRH-1 in adipose tissue.

Clyne CD, Kovacic A, Speed CJ, Zhou J, Pezzi V, Simpson ER.

Mol Cell Endocrinol. 2004 Feb 27;215(1-2):39-44. Review.


Activation of nuclear receptors: a perspective from structural genomics.

Li Y, Lambert MH, Xu HE.

Structure. 2003 Jul;11(7):741-6. Review.

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