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J Virol. 1998 Aug;72(8):6907-10.

Recombinant Sindbis viruses expressing a cytotoxic T-lymphocyte epitope of a malaria parasite or of influenza virus elicit protection against the corresponding pathogen in mice.

Author information

1
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York 10010, USA.

Abstract

Subcutaneous administration in mice of recombinant Sindbis viruses expressing a class I major histocompatibility complex-restricted 9-mer epitope of the Plasmodium yoelii circumsporozoite protein or the nucleoprotein of influenza virus induces a large epitope-specific CD8(+) T-cell response. This immunization also elicits a high degree of protection against infection with malaria or influenza A virus.

PMID:
9658144
PMCID:
PMC109904
[Indexed for MEDLINE]
Free PMC Article

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