Format

Send to

Choose Destination
Eur J Clin Pharmacol. 1998 Apr;54(2):159-61.

Effect of omeprazole on the pharmacokinetics of itraconazole.

Author information

1
Department of Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.

Abstract

OBJECTIVE:

To investigate the effect of omeprazole on the pharmacokinetics of itraconazole.

METHODS:

Eleven healthy volunteers received a single dose of oral itraconazole (200 mg) on days 1 and 15 and oral omeprazole (40 mg) once daily from day 2 to day 15. Itraconazole pharmacokinetics were studied on days 1 and 15.

RESULTS:

Concentrations of itraconazole were higher when it was taken alone than when it was taken with omeprazole. With concomitant omeprazole treatment, the mean AUC0-24 and Cmax of itraconazole were significantly reduced by 64% and 66%, respectively.

CONCLUSION:

Omeprazole affects itraconazole kinetics, leading to a reduction in bioavailability and Cmax. These two drugs should not be used together.

PMID:
9626921
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center