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J Comp Pathol. 1996 Oct;115(3):253-63.

Growth of Newcastle disease virus in chicken macrophages.

Author information

1
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis 95616, USA.

Abstract

Chicken macrophages were isolated from chicken peripheral blood, cultured in vitro, and infected with Newcastle disease virus (NDV) after reaching semiconfluence. Infected macrophages supported the growth and replication of NDV. Virus-infected macrophages exhibited features of apoptosis as determined by agarose gel electrophoresis, thymidine release assays and flow cytometry. Electron microscopical examination also showed the appearance of intact virus particles, fragmented chromatin and apoptotic bodies. This evidence demonstrates that NDV infection of chicken macrophages causes chicken macrophages to undergo apoptosis.

PMID:
8923236
DOI:
10.1016/s0021-9975(96)80083-1
[Indexed for MEDLINE]

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