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Lancet. 1993 Jun 5;341(8858):1439-40.

Colorectal cancer in patients with X-linked agammaglobulinaemia.

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Department of General Internal Medicine, University Hospital Nijmegen, Netherlands.


Primary immunodeficiency disorders can predispose to certain malignancies but hitherto no such relation has been established for X-linked agammaglobulinaemia (XLA). We have diagnosed rapidly progressive colorectal cancer in 3 unrelated young adults with XLA. We could find no explanation for the tumours. Since the calculated incidence of rectosigmoid cancer is increased 30-fold in patients with XLA, we advise the screening of these individuals, and perhaps people with other agammaglobulinaemias, for colorectal cancer.

[Indexed for MEDLINE]

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