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Proc Natl Acad Sci U S A. 1987 Dec;84(23):8712-5.

Grafted noradrenergic neurons suppress seizure development in kindling-induced epilepsy.

Author information

1
Department of Psychiatry, Rigshospitalet, University of Copenhagen, Denmark.

Abstract

Norepinephrine-rich cell suspensions, prepared from the locus coeruleus region of rat fetuses, were grafted bilaterally into the hippocampus of rats made hypersensitive to hippocampal kindling by a neurotoxic lesion of the central catecholamine system. The animals with grafts showed a marked suppression of the onset and progression of kindling-induced epilepsy, and this effect was correlated with the degree of graft-derived noradrenergic innervation of the host hippocampal formation. We conclude that grafted neurons can modulate the excitability of epileptic brain regions.

PMID:
3120197
PMCID:
PMC299616
DOI:
10.1073/pnas.84.23.8712
[Indexed for MEDLINE]
Free PMC Article

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