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Curr Opin Chem Biol. 2018 Aug;45:48-56. doi: 10.1016/j.cbpa.2018.02.006. Epub 2018 Mar 2.

DNA methylation as a genomic marker of exposure to chemical and environmental agents.

Author information

1
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK. Electronic address: richard.meehan@igmm.ed.ac.uk.
2
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK.
3
Department of Clinical and Experimental Medicine, Linköping University, Linköping SE 58183, Sweden.
4
Department of Clinical and Experimental Medicine, Linköping University, Linköping SE 58183, Sweden. Electronic address: colm.nestor@liu.se.
5
Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, EH16 4TJ, UK. Electronic address: sari.pennings@ed.ac.uk.

Abstract

Recent progress in interpreting comprehensive genetic and epigenetic profiles for human cellular states has contributed new insights into the developmental origins of disease, elucidated novel signalling pathways and enhanced drug discovery programs. A similar comprehensive approach to decoding the epigenetic readouts from chemical challenges in vivo would yield new paradigms for monitoring and assessing environmental exposure in model systems and humans.

PMID:
29505975
DOI:
10.1016/j.cbpa.2018.02.006
[Indexed for MEDLINE]
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