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Physiol Behav. 2018 May 1;188:119-127. doi: 10.1016/j.physbeh.2018.02.005. Epub 2018 Feb 3.

Autophagy mediates the degradation of synaptic vesicles: A potential mechanism of synaptic plasticity injury induced by microwave exposure in rats.

Author information

1
Department of Experimental Pathology, Institute of Radiation Medicine, Beijing, PR China.
2
Division of Radiation Protection and Health Physics, Institute of Radiation Medicine, Beijing, PR China.
3
Department of Experimental Pathology, Institute of Radiation Medicine, Beijing, PR China. Electronic address: lillyliz@163.com.
4
Department of Experimental Pathology, Institute of Radiation Medicine, Beijing, PR China. Electronic address: pengry@bmi.ac.cn.

Abstract

To explore how autophagy changes and whether autophagy is involved in the pathophysiological process of synaptic plasticity injury caused by microwave radiation, we established a 30 mW/cm2 microwave-exposure in vivo model, which caused reversible injuries in rat neurons. Microwave radiation induced cognitive impairment in rats and synaptic plasticity injury in rat hippocampal neurons. Autophagy in rat hippocampal neurons was activated following microwave exposure. Additionally, we observed that synaptic vesicles were encapsulated by autophagosomes, a phenomenon more evident in the microwave-exposed group. Colocation of autophagosomes and synaptic vesicles in rat hippocampal neurons increased following microwave exposure.

CONCLUSION:

microwave exposure led to the activation of autophagy in rat hippocampal neurons, and excessive activation of autophagy might damage synaptic plasticity by mediating synaptic vesicle degradation.

KEYWORDS:

Autophagy; Hippocampus; Microwave; Rats; Synaptic plasticity

PMID:
29408588
DOI:
10.1016/j.physbeh.2018.02.005
[Indexed for MEDLINE]

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