Format

Send to

Choose Destination
Trends Cell Biol. 2018 Mar;28(3):171-173. doi: 10.1016/j.tcb.2018.01.001. Epub 2018 Jan 31.

Autophagy in Neurodegeneration: Can't Digest It, Spit It Out!

Author information

1
Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
2
Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK. Electronic address: k.ryan@beatson.gla.ac.uk.

Abstract

The autophagy-lysosome pathway maintains cellular homeostasis and protects against neurodegenerative disorders. Recent findings show that autophagy can be impaired in these diseases, and that the cell activates an alternative Golgi-mediated degradation pathway, leading to expulsion of toxic protein aggregates. Ultimately this process leads to nuclear breakdown and neuronal cell death.

KEYWORDS:

Golgi apparatus; autophagy; cellular excretion; neurodegeneration; nucleophagy

PMID:
29395716
DOI:
10.1016/j.tcb.2018.01.001
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center