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Neuron. 2017 Sep 13;95(6):1420-1432.e5. doi: 10.1016/j.neuron.2017.08.036.

A Sensorimotor Circuit in Mouse Cortex for Visual Flow Predictions.

Author information

1
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
2
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland; Faculty of Natural Sciences, University of Basel, Basel, Switzerland.
3
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland; Faculty of Natural Sciences, University of Basel, Basel, Switzerland. Electronic address: georg.keller@fmi.ch.

Abstract

The cortex is organized as a hierarchical processing structure. Feedback from higher levels of the hierarchy, known as top-down signals, have been shown to be involved in attentional and contextual modulation of sensory responses. Here we argue that top-down input to the primary visual cortex (V1) from A24b and the adjacent secondary motor cortex (M2) signals a prediction of visual flow based on motor output. A24b/M2 sends a dense and topographically organized projection to V1 that targets most neurons in layer 2/3. By imaging the activity of A24b/M2 axons in V1 of mice learning to navigate a 2D virtual environment, we found that their activity was strongly correlated with locomotion and resulting visual flow feedback in an experience-dependent manner. When mice were trained to navigate a left-right inverted virtual environment, correlations of neural activity with behavior reversed to match visual flow. These findings are consistent with a predictive coding interpretation of visual processing.

KEYWORDS:

A24b; anterior cingulate cortex; predictive coding; sensorimotor integration; visual cortex

PMID:
28910624
DOI:
10.1016/j.neuron.2017.08.036
[Indexed for MEDLINE]
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