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Neurosci Bull. 2017 Oct;33(5):576-584. doi: 10.1007/s12264-017-0164-8. Epub 2017 Aug 3.

Clinical Significance of REM Sleep Behavior Disorders and Other Non-motor Symptoms of Parkinsonism.

Author information

1
Department of Neurology and Sleep Center, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
2
Department of Neurology and Sleep Center, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. liuchunfeng@suda.edu.cn.
3
Institute of Neuroscience, Soochow University, Suzhou, 215123, China. liuchunfeng@suda.edu.cn.

Abstract

Rapid eye movement sleep behavior disorder (RBD) is one of the most common non-motor symptoms of parkinsonism, and it may serve as a prodromal marker of neurodegenerative disease. The mechanism underlying RBD is unclear. Several prospective studies have reported that specific non-motor symptoms predict a conversion risk of developing a neurodegenerative disease, including olfactory dysfunction, abnormal color vision, autonomic dysfunction, excessive daytime sleepiness, depression, and cognitive impairment. Parkinson's disease (PD) with RBD exhibits clinical heterogeneity with respect to motor and non-motor symptoms compared with PD without RBD. In this review, we describe the main clinical and pathogenic features of RBD, focusing on its association with other non-motor symptoms of parkinsonism.

KEYWORDS:

Parkinsonism; Parkinson’s disease; Rapid eye movement sleep behavior disorder; Risk factors

PMID:
28770440
PMCID:
PMC5636735
DOI:
10.1007/s12264-017-0164-8
[Indexed for MEDLINE]
Free PMC Article

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