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J Physiol Sci. 2018 Sep;68(5):531-540. doi: 10.1007/s12576-017-0558-4. Epub 2017 Jul 8.

Insulin does not rescue cortical and trabecular bone loss in type 2 diabetic Goto-Kakizaki rats.

Author information

1
Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok, 10400, Thailand.
2
Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol University, Bangkok, Thailand.
3
Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok, 10400, Thailand. naratt@narattsys.com.
4
Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol University, Bangkok, Thailand. naratt@narattsys.com.
5
Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand. naratt@narattsys.com.
6
Office of Academic Management, Faculty of Allied Health Sciences, Burapha University, Chonburi, Thailand.
7
Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
8
National Laboratory Animal Center, Mahidol University, Nakhon Pathom, Thailand.

Abstract

In type 2 diabetes mellitus (T2DM), the decreased bone strength is often associated with hyperglycemia and bone cell insulin resistance. Since T2DM is increasingly reported in young adults, it is not known whether the effect of T2DM on bone would be different in young adolescents and aging adults. Here, we found shorter femoral and tibial lengths in 7-month, but not 13-month, Goto-Kakizaki (GK) T2DM rats as compared to wild-type rats. Bone ┬ÁCT analysis showed long-lasting impairment of both cortical and trabecular bones in GK rats. Although insulin treatment effectively improved hyperglycemia, it was not able to rescue trabecular BMD and cortical thickness in young adult GK rats. In conclusion, insulin treatment and alleviation of hyperglycemia did not increase BMD of osteopenic GK rats. It is likely that early prevention of insulin resistance should prevail over treatment of full-blown T2DM-related osteopathy.

KEYWORDS:

Blood glucose; Bone mineral density; Diabetes mellitus; Diabetic osteopathy; Goto-Kakizaki rats

PMID:
28689272
DOI:
10.1007/s12576-017-0558-4

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