Format

Send to

Choose Destination
Oxid Med Cell Longev. 2017;2017:1703810. doi: 10.1155/2017/1703810. Epub 2017 Mar 27.

Involvement of Nrf2 in Ocular Diseases.

Author information

1
Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
2
Department of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
3
North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

Abstract

The human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focuses on the effects of oxidative stress and the role of a particular antioxidant system-the Keap1-Nrf2-ARE pathway-on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. Together, they are the major causes of blindness in the world.

PMID:
28473877
PMCID:
PMC5394909
DOI:
10.1155/2017/1703810
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Hindawi Limited Icon for PubMed Central
Loading ...
Support Center