Format

Send to

Choose Destination
Neuron. 2017 May 3;94(3):447-464. doi: 10.1016/j.neuron.2017.02.047.

The Mechanisms and Functions of Synaptic Facilitation.

Author information

1
Department of Neurobiology, Harvard Medical School, Boston, MA 02118, USA.
2
Department of Neurobiology, Harvard Medical School, Boston, MA 02118, USA. Electronic address: wade_regehr@hms.harvard.edu.

Abstract

The ability of the brain to store and process information relies on changing the strength of connections between neurons. Synaptic facilitation is a form of short-term plasticity that enhances synaptic transmission for less than a second. Facilitation is a ubiquitous phenomenon thought to play critical roles in information transfer and neural processing. Yet our understanding of the function of facilitation remains largely theoretical. Here we review proposed roles for facilitation and discuss how recent progress in uncovering the underlying molecular mechanisms could enable experiments that elucidate how facilitation, and short-term plasticity in general, contributes to circuit function and animal behavior.

KEYWORDS:

active zone; calcium channel; exocytosis; facilitation; neurotransmitter release; release probability; synapse; synaptic plasticity; synaptic vesicle; synaptotagmin

PMID:
28472650
PMCID:
PMC5865607
DOI:
10.1016/j.neuron.2017.02.047
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center