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Neuroimage Clin. 2017 Feb 24;14:566-573. doi: 10.1016/j.nicl.2017.02.018. eCollection 2017.

Physiological and pathological high-frequency oscillations have distinct sleep-homeostatic properties.

Author information

1
Montreal Neurological Institute and Hospital, McGill University, 3801 University Street, Montreal H3A 2B4, Québec, Canada.
2
Montreal Neurological Institute and Hospital, McGill University, 3801 University Street, Montreal H3A 2B4, Québec, Canada; Department of Medicine and Center for Neuroscience Studies, Queen's University, 18 Stuart Street, Kingston K7L3N6, Ontario, Canada.

Abstract

OBJECTIVE:

The stage of sleep is a known modulator of high-frequency oscillations (HFOs). For instance, high amplitude slow waves during NREM sleep and the subtypes of REM sleep were shown to contribute to a better separation between physiological and pathological HFOs. This study investigated rates and spatial spread of the different HFO types (physiological and pathological ripples in the 80-250 Hz frequency band, and fast ripples above 250 Hz) depending on time spent in sleep across the different sleep cycles.

METHODS:

Fifteen patients with focal pharmaco-resistant epilepsy underwent one night of video-polysomnography during chronic intracranial EEG recording for presurgical epilepsy evaluation. The HFO rate and spread across the different sleep cycles were determined with an automatic HFO detector. We built models to explain the observed rate and spread based on time in sleep and other variables i.e. sleep stage, delta band and sigma band activity, and slow wave amplitude. Statistical significance of the different variables was determined by a model comparison using the Akaike information criterion.

RESULTS:

The rate of HFOs depends significantly on the accumulated time of sleep. As the night advanced, the rate of pathological ripples and fast ripples decreased during NREM sleep (up to 15% per hour spent in the respective sleep stages), while the rate of physiological ripples increased during REM sleep (8% per hour spent in REM sleep). Interestingly, the stage of sleep but not the sleep cycle determined the extent of spread of HFOs, showing a larger field during NREM sleep and a more restricted field during REM sleep.

CONCLUSION:

The different dependence with sleep time for physiological and pathological ripples is in keeping with their distinct underlying generating mechanisms. From a practical point of view, the first sleep cycle seems to be best suitable for studying HFOs in epilepsy, given that the contrast between physiological and pathological ripple rates is largest during this time.

KEYWORDS:

Epilepsy; High frequency oscillations; Intracerebral EEG; Polysomnography; Sleep

PMID:
28337411
PMCID:
PMC5349616
DOI:
10.1016/j.nicl.2017.02.018
[Indexed for MEDLINE]
Free PMC Article

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