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Euro Surveill. 2017 Feb 23;22(8). pii: 30466. doi: 10.2807/1560-7917.ES.2017.22.8.30466.

Emergence of a novel subclade of influenza A(H3N2) virus in London, December 2016 to January 2017.

Author information

1
Department of Clinical Virology, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
2
Department of Infection and Immunity, University College of London, London, United Kingdom.
3
NIHR UCLH/UCL Biomedical Research Centre, London, United Kingdom.
4
Department of Medicine, Imperial College Faculty of Medicine, London, United Kingdom.
5
Department of Infectious Disease Informatics, Farr Institute of Health Informatics Research, London, United Kingdom.
6
Department of Population, Policy and Practice, UCL GOS Institute of Child Health, London, United Kingdom.
7
The members of these networks are listed at the end of the article.

Erratum in

Abstract

We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity.

KEYWORDS:

influenza; molecular; next generation sequencing; outbreak

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