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Euro Surveill. 2017 Feb 23;22(8). pii: 30466. doi: 10.2807/1560-7917.ES.2017.22.8.30466.

Emergence of a novel subclade of influenza A(H3N2) virus in London, December 2016 to January 2017.

Author information

Department of Clinical Virology, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
Department of Infection and Immunity, University College of London, London, United Kingdom.
NIHR UCLH/UCL Biomedical Research Centre, London, United Kingdom.
Department of Medicine, Imperial College Faculty of Medicine, London, United Kingdom.
Department of Infectious Disease Informatics, Farr Institute of Health Informatics Research, London, United Kingdom.
Department of Population, Policy and Practice, UCL GOS Institute of Child Health, London, United Kingdom.
The members of these networks are listed at the end of the article.

Erratum in


We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity.


influenza; molecular; next generation sequencing; outbreak

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