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Neurosci Bull. 2017 Feb;33(1):62-72. doi: 10.1007/s12264-016-0089-7. Epub 2016 Dec 19.

A New Perspective for Parkinson's Disease: Circadian Rhythm.

Li S1,2, Wang Y1,2, Wang F2, Hu LF2, Liu CF3,4.

Author information

1
Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
2
Institutes of Neuroscience, Soochow University, Suzhou, 215123, China.
3
Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. liuchunfeng@suda.edu.cn.
4
Institutes of Neuroscience, Soochow University, Suzhou, 215123, China. liuchunfeng@suda.edu.cn.

Abstract

Circadian rhythm is manifested by the behavioral and physiological changes from day to night, which is controlled by the pacemaker and its regulator. The former is located at the suprachiasmatic nuclei (SCN) in the anterior hypothalamus, while the latter is composed of clock genes present in all tissues. Circadian desynchronization influences normal patterns of day-night rhythms such as sleep and alertness cycles, rest and activity cycles. Parkinson's disease (PD) exhibits diurnal fluctuations. Circadian dysfunction has been observed in PD patients and animal models, which may result in negative consequences to the homeostasis and even exacerbate the disease progression. Therefore, circadian therapies, including light stimulation, physical activity, dietary and social schedules, may be helpful for PD patients. However, the cellular and molecular mechanisms that underlie the circadian dysfunction in PD remain elusive. Further research on circadian patterns is needed. This article summarizes the existing research on the circadian rhythms in PD, focusing on the clinical symptom variations, molecular changes, as well as the available treatment options.

KEYWORDS:

Circadian rhythm; Dopamine; Parkinson’s disease; Sleep

PMID:
27995565
PMCID:
PMC5567551
DOI:
10.1007/s12264-016-0089-7
[Indexed for MEDLINE]
Free PMC Article

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