Format

Send to

Choose Destination
Immunity. 2016 Nov 15;45(5):956-958. doi: 10.1016/j.immuni.2016.10.030.

BTLA+ Dendritic Cells: The Regulatory T Cell Force Awakens.

Author information

1
Department of Surgery, University of Maryland School of Medicine, 29 South Greene Street, Baltimore, MD 21201, USA; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, 800 West Baltimore Street, Baltimore, MD 21201, USA.
2
Department of Surgery, University of Maryland School of Medicine, 29 South Greene Street, Baltimore, MD 21201, USA; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, 800 West Baltimore Street, Baltimore, MD 21201, USA; Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA; Marlene and Stewart Greenebaum Cancer Center, 22 South Greene Street, Baltimore, MD 21201, USA. Electronic address: jbromberg@smail.umaryland.edu.

Abstract

The role of dendritic cells (DCs) in the induction of antigen-specific tolerance mediated by extrathymic regulatory T (Treg) cells remains incompletely defined. In this issue of Immunity, Jones et al. (2016) show that BTLA+DEC205+CD8+CD11c+ DCs efficiently induce peripheral Treg cells via the engagement of HVEM, a receptor for BTLA.

PMID:
27851922
DOI:
10.1016/j.immuni.2016.10.030
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center