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Dokl Biol Sci. 2016 Jul;469(1):163-6. doi: 10.1134/S0012496616040153. Epub 2016 Sep 7.

Myelinated fibers of the mouse spinal cord after a 30-day space flight.

Author information

1
Kazan State Medical University, Kazan, Tatarstan, Russia. t.povysheva@gmail.com.
2
Kazan (Volga Region) Federal University, Kazan, Tatarstan, Russia. t.povysheva@gmail.com.
3
Kazan State Medical University, Kazan, Tatarstan, Russia.
4
Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, Kazan, Tatarstan, Russia.
5
Kazan (Volga Region) Federal University, Kazan, Tatarstan, Russia.
6
Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.

Abstract

Myelinated fibers and myelin-forming cells in the spinal cord at the L3-L5 level were studied in C57BL/6N mice that had spent 30 days in space. Signs of destruction of myelin in different areas of white matter, reduction of the thickness of myelin sheath and axon diameter, decreased number of myelin-forming cells were detected in "flight" mice. The stay of mice in space during 30 days had a negative impact on the structure of myelinated fibers and caused reduced expression of the markers myelin-forming cells. These findings can complement the pathogenetic picture of the development of hypogravity motor syndrome.

PMID:
27595822
DOI:
10.1134/S0012496616040153
[Indexed for MEDLINE]

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