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J Genet Genomics. 2016 Aug 20;43(8):481-94. doi: 10.1016/j.jgg.2016.06.002. Epub 2016 Jun 30.

Argonaute: The executor of small RNA function.

Author information

1
School of Biological Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia.
2
School of Biological Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia; Advance Medical and Dental Institute, Universiti Sains Malaysia, Penang 11800, Malaysia. Electronic address: ghows@usm.my.

Abstract

The discovery of small non-coding RNAs - microRNA (miRNA), short interfering RNA (siRNA) and PIWI-interacting RNA (piRNA) - represents one of the most exciting frontiers in biology specifically on the mechanism of gene regulation. In order to execute their functions, these small RNAs require physical interactions with their protein partners, the Argonaute (AGO) family proteins. Over the years, numerous studies have made tremendous progress on understanding the roles of AGO in gene silencing in various organisms. In this review, we summarize recent progress of AGO-mediated gene silencing and other cellular processes in which AGO proteins have been implicated with a particular focus on progress made in flies, humans and other model organisms as compliment.

KEYWORDS:

Argonaute; Drosophila melanogaster; Gene silencing; Human; Model organisms; RNAi; Small RNAs

PMID:
27569398
DOI:
10.1016/j.jgg.2016.06.002
[Indexed for MEDLINE]

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