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Autoimmun Rev. 2016 Sep;15(9):890-5. doi: 10.1016/j.autrev.2016.07.009. Epub 2016 Jul 5.

The role of B cells and autoantibodies in neuropsychiatric lupus.

Author information

1
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, United States.
2
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, United States; Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, United States. Electronic address: chaim.putterman@einstein.yu.edu.

Abstract

The central nervous system manifestations of SLE (neuropsychiatric lupus, NPSLE) occur frequently, though are often difficult to diagnose and treat. Symptoms of NPSLE can be quite diverse, including chronic cognitive and emotional manifestations, as well as acute presentations, such as stroke and seizures. Although the pathogenesis of NPSLE has yet to be well characterized, B-cell mediated damage is believed to be an important contributor. B-cells and autoantibodies may traverse the blood brain barrier promoting an inflammatory environment consisting of glia activation, neurodegeneration, and consequent averse behavioral outcomes. This review will evaluate the various suggested roles of B-cells and autoantibodies in NPSLE, as well as therapeutic modalities targeting these pathogenic mediators.

KEYWORDS:

Autoantibodies; B cells; Neuropsychiatric lupus; SLE

PMID:
27389531
PMCID:
PMC4982790
DOI:
10.1016/j.autrev.2016.07.009
[Indexed for MEDLINE]
Free PMC Article

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