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J Virol. 2016 Jun 10;90(13):5850-5854. doi: 10.1128/JVI.01979-15. Print 2016 Jul 1.

Emerging Role of PML Nuclear Bodies in Innate Immune Signaling.

Author information

1
Institute for Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
2
Institute for Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany thomas.stamminger@viro.med.uni-erlangen.de.

Abstract

Research in the last 2 decades has demonstrated that a specific organelle of the cell nucleus, termed PML nuclear body (PML-NB) or nuclear domain 10 (ND10), is frequently modified during viral infection. This correlates with antagonization of a direct repressive function of individual PML-NB components, such as the PML, hDaxx, Sp100, or ATRX protein, that are able to act as cellular restriction factors. Recent studies now reveal an emerging role of PML-NBs as coregulatory structures of both type I and type II interferon responses. This emphasizes that targeting of PML-NBs by viral regulatory proteins has evolved as a strategy to compromise intrinsic antiviral defense and innate immune responses.

PMID:
27053550
PMCID:
PMC4907236
DOI:
10.1128/JVI.01979-15
[Indexed for MEDLINE]
Free PMC Article

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