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Exp Mol Med. 2016 Mar 11;48:e216. doi: 10.1038/emm.2016.4.

Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism.

Roh E1,2, Song DK1,3, Kim MS1,3.

Author information

1
Appeptite Regulation Laboratory, Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea.
2
Department of Medicine, University of Ulsan College of Medicine, Seoul, Korea.
3
Division of Endocrinology and Metabolism, Asan Medical Center, Seoul, Korea.

Abstract

Accumulated evidence from genetic animal models suggests that the brain, particularly the hypothalamus, has a key role in the homeostatic regulation of energy and glucose metabolism. The brain integrates multiple metabolic inputs from the periphery through nutrients, gut-derived satiety signals and adiposity-related hormones. The brain modulates various aspects of metabolism, such as food intake, energy expenditure, insulin secretion, hepatic glucose production and glucose/fatty acid metabolism in adipose tissue and skeletal muscle. Highly coordinated interactions between the brain and peripheral metabolic organs are critical for the maintenance of energy and glucose homeostasis. Defective crosstalk between the brain and peripheral organs contributes to the development of obesity and type 2 diabetes. Here we comprehensively review the above topics, discussing the main findings related to the role of the brain in the homeostatic regulation of energy and glucose metabolism.

PMID:
26964832
PMCID:
PMC4892882
DOI:
10.1038/emm.2016.4
[Indexed for MEDLINE]
Free PMC Article

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