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J Alzheimers Dis. 2016;51(4):1099-109. doi: 10.3233/JAD-151028.

Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy.

Author information

1
Boston University Alzheimer's Disease and CTE Center, Boston, MA, USA.
2
Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
3
Department of Neurosurgery, Boston University School of Medicine, Boston, MA, USA.
4
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.
5
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
6
Data Coordinating Center, Boston University School of Public Health, Boston, MA, USA.
7
Department of Neurosurgery, Emerson Hospital, Concord, MA, USA.
8
Aethlon Medical, San Diego, CA, USA.
9
Exosome Sciences, San Diego, USA.
10
Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
11
Department of Pathology, University of Washington, Seattle, WA, USA.

Abstract

BACKGROUND:

Chronic traumatic encephalopathy (CTE) is a tauopathy associated with prior exposure to repetitive head impacts, such as those incurred through American football and other collision sports. Diagnosis is made through neuropathological examination. Many of the clinical features of CTE are common in the general population, with and without a history of head impact exposure, making clinical diagnosis difficult. As is now common in the diagnosis of other neurodegenerative disorders, such as Alzheimer's disease, there is a need for methods to diagnose CTE during life through objective biomarkers.

OBJECTIVE:

The aim of this study was to examine tau-positive exosomes in plasma as a potential CTE biomarker.

METHODS:

Subjects were 78 former National Football League (NFL) players and 16 controls. Extracellular vesicles were isolated from plasma. Fluorescent nanoparticle tracking analysis was used to determine the number of vesicles staining positive for tau.

RESULTS:

The NFL group had higher exosomal tau than the control group (p <  0.0001). Exosomal tau discriminated between the groups, with 82% sensitivity, 100% specificity, 100% positive predictive value, and 53% negative predictive value. Within the NFL group, higher exosomal tau was associated with worse performance on tests of memory (p = 0.0126) and psychomotor speed (p = 0.0093).

CONCLUSION:

These preliminary findings suggest that exosomal tau in plasma may be an accurate, noninvasive CTE biomarker.

KEYWORDS:

Biomarker; chronic traumatic encephalopathy; diagnosis; exosome; football; neurodegeneration; plasma; tau

PMID:
26890775
PMCID:
PMC4833534
DOI:
10.3233/JAD-151028
[Indexed for MEDLINE]
Free PMC Article

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