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Front Cell Infect Microbiol. 2016 Feb 3;6:1. doi: 10.3389/fcimb.2016.00001. eCollection 2016.

Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture.

Author information

1
Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University Xi'an, China.
2
Department of Microbiology, School of Basic Medicine, Fourth Military Medical University Xi'an, China.

Abstract

Hantaan virus (HTNV) causes hemorrhagic fever with renal syndrome (HFRS), which is a zoonosis endemic in eastern Asia, especially in China. The reservoir host of HTNV is field mouse (Apodemus agraricus). The main manifestation of HFRS, including acute kidney injury, increases vascular permeability, and coagulation abnormalities. In this paper, we review the current knowledge of the pathogenesis of HFRS including virus factor, immunity factor and host genetic factors. Furthermore, the treatment and prevention will be discussed.

KEYWORDS:

Bunyavirus; hantaan virus; hantavirus; hemorrhagic fever with renal syndrome; pathogenesis

PMID:
26870699
PMCID:
PMC4737898
DOI:
10.3389/fcimb.2016.00001
[Indexed for MEDLINE]
Free PMC Article

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