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Mar Drugs. 2016 Jan 28;14(2). pii: E30. doi: 10.3390/md14020030.

Yessotoxin, a Promising Therapeutic Tool.

Author information

1
Department of Pharmacology, Faculty of Veterinary, University of Santiago of Compostela, 27002 Lugo, Spain. amparo.alfonso@usc.es.
2
Department of Physiology, Faculty of Veterinary, University of Santiago of Compostela, 27002 Lugo, Spain. mmercedes.rodriguez@usc.es.
3
Department of Physiology, Faculty of Veterinary, University of Santiago of Compostela, 27002 Lugo, Spain. luis.botana@usc.es.

Abstract

Yessotoxin (YTX) is a polyether compound produced by dinoflagellates and accumulated in filter feeding shellfish. No records about human intoxications induced by this compound have been published, however it is considered a toxin. Modifications in second messenger levels, protein levels, immune cells, cytoskeleton or activation of different cellular death types have been published as consequence of YTX exposure. This review summarizes the main intracellular pathways modulated by YTX and their pharmacological and therapeutic implications.

KEYWORDS:

Alzheimer; apoptosis; autophagy; cellular death; cytoskeleton; glucose metabolism; immune system; signal transduction; yessotoxin (YTX)

PMID:
26828502
PMCID:
PMC4771983
DOI:
10.3390/md14020030
[Indexed for MEDLINE]
Free PMC Article

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