Format

Send to

Choose Destination
J Exp Med. 2016 Jan 11;213(1):15-23. doi: 10.1084/jem.20151570. Epub 2015 Dec 22.

Immunometabolism governs dendritic cell and macrophage function.

Author information

1
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland laoneill@tcd.ie pearceed@ie-freiburg.mpg.de.
2
Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, D-79108 Freiburg, Germany laoneill@tcd.ie pearceed@ie-freiburg.mpg.de.

Abstract

Recent studies on intracellular metabolism in dendritic cells (DCs) and macrophages provide new insights on the functioning of these critical controllers of innate and adaptive immunity. Both cell types undergo profound metabolic reprogramming in response to environmental cues, such as hypoxia or nutrient alterations, but importantly also in response to danger signals and cytokines. Metabolites such as succinate and citrate have a direct impact on the functioning of macrophages. Immunogenicity and tolerogenicity of DCs is also determined by anabolic and catabolic processes, respectively. These findings provide new prospects for therapeutic manipulation in inflammatory diseases and cancer.

PMID:
26694970
PMCID:
PMC4710204
DOI:
10.1084/jem.20151570
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center