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J Biol Chem. 2016 Feb 26;291(9):4334-41. doi: 10.1074/jbc.R115.704981. Epub 2015 Dec 22.

The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases.

Author information

1
From the Department of Neurology, University of Bonn, 53127 Bonn, Germany jochen.walter@ukb.uni-bonn.de.

Abstract

The triggering receptor expressed on myeloid cells (TREM) 2 is a member of the immunoglobulin superfamily of receptors and mediates signaling in immune cells via engagement of its co-receptor DNAX-activating protein of 12 kDa (DAP12). Homozygous mutations in TREM2 or DAP12 cause Nasu-Hakola disease, which is characterized by bone abnormalities and dementia. Recently, a variant of TREM2 has also been associated with an increased risk for Alzheimer disease. The selective expression of TREM2 on immune cells and its association with different forms of dementia indicate a contribution of this receptor in common pathways of neurodegeneration.

KEYWORDS:

Alzheimer disease; cell signaling; microglia; neurodegenerative disease; neuroinflammation; protein processing

PMID:
26694609
PMCID:
PMC4813462
[Available on 2017-02-26]
DOI:
10.1074/jbc.R115.704981
[Indexed for MEDLINE]
Free PMC Article

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