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Cell. 2015 Nov 19;163(5):1064-1078. doi: 10.1016/j.cell.2015.10.067.

Establishment and Dysfunction of the Blood-Brain Barrier.

Author information

1
Department of Physiology and Biophysics and the Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA.
2
Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, 75185 Uppsala, Sweden.
3
Department of Physiology and Biophysics and the Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA. Electronic address: zlokovic@usc.edu.

Abstract

Structural and functional brain connectivity, synaptic activity, and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions. Here, we examine the mechanisms regulating the formation and maintenance of the BBB and functions of BBB-associated cell types. Furthermore, we discuss the growing evidence associating BBB breakdown with the pathogenesis of inherited monogenic neurological disorders and complex multifactorial diseases, including Alzheimer's disease.

PMID:
26590417
PMCID:
PMC4655822
DOI:
10.1016/j.cell.2015.10.067
[Indexed for MEDLINE]
Free PMC Article

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