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Alzheimers Dement. 2016 Apr;12(4):373-9. doi: 10.1016/j.jalz.2015.08.166. Epub 2015 Nov 14.

Individual estimates of age at detectable amyloid onset for risk factor assessment.

Author information

1
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute on Aging, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA. Electronic address: murat.bilgel@nih.gov.
2
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.
3
Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
4
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA; Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA.
5
Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.

Abstract

INTRODUCTION:

Individualized estimates of age at detectable amyloid-beta (Aβ) accumulation, distinct from amyloid positivity, allow for analysis of onset age of Aβ accumulation as an outcome measure to understand risk factors.

METHODS:

Using longitudinal Pittsburgh compound B (PiB) positron emission tomography data from Baltimore Longitudinal Study of Aging, we estimated the age at which each PiB+ individual began accumulating Aβ. We used survival analysis methods to quantify risk of accumulating Aβ and differences in onset age of Aβ accumulation in relation to APOE ε4 status and sex among 36 APOE ε4 carriers and 83 noncarriers.

RESULTS:

Age at onset of Aβ accumulation for the APOE ε4- and ε4+ groups was 73.1 and 60.7, respectively. APOE ε4 positivity conferred a threefold risk of accumulating Aβ after adjusting for sex and education.

DISCUSSION:

Estimation of onset age of amyloid accumulation may help gauge treatment efficacy in interventions to delay symptom onset in Alzheimer's disease.

KEYWORDS:

APOE; Age at onset; Amyloid imaging; PET; Pittsburgh compound B

PMID:
26588863
PMCID:
PMC4841700
DOI:
10.1016/j.jalz.2015.08.166
[Indexed for MEDLINE]
Free PMC Article

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