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J Control Release. 2015 Dec 10;219:76-94. doi: 10.1016/j.jconrel.2015.09.039. Epub 2015 Sep 25.

Magnetic nanoparticles and nanocomposites for remote controlled therapies.

Author information

1
Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA.
2
Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA. Electronic address: hilt@engr.uky.edu.

Abstract

This review highlights the state-of-the-art in the application of magnetic nanoparticles (MNPs) and their composites for remote controlled therapies. Novel macro- to nano-scale systems that utilize remote controlled drug release due to actuation of MNPs by static or alternating magnetic fields and magnetic field guidance of MNPs for drug delivery applications are summarized. Recent advances in controlled energy release for thermal therapy and nanoscale energy therapy are addressed as well. Additionally, studies that utilize MNP-based thermal therapy in combination with other treatments such as chemotherapy or radiation to enhance the efficacy of the conventional treatment are discussed.

KEYWORDS:

Magnetic nanoparticles; Nanocomposites; Remote controlled drug delivery

PMID:
26407670
PMCID:
PMC4669063
DOI:
10.1016/j.jconrel.2015.09.039
[Indexed for MEDLINE]
Free PMC Article

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