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J Gen Virol. 2015 Sep;96(9):2579-2586. doi: 10.1099/jgv.0.000228. Epub 2015 Jun 30.

Expression of Raf kinase inhibitor protein is downregulated in response to Newcastle disease virus infection to promote viral replication.

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Department of Veterinary Preventive Medicine, College of Veterinary Medicine, Jilin University, Xi'an Road 5333, Changchun, Jilin 130062, PR China.
College of Quartermaster Technology Science, Jilin University, Xi'an Road 5333, Changchun, Jilin 130062, PR China.
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China.
China Animal Health and Epidemiology Center, Qingdao, Nanjing Road 369, Qingdao, Shandong 266032, PR China.
Comprehensive Pneumology Center, Institute of Lung Biology and Disease (iLBD), Helmholtz Zentrum München, Ingolstädter Landstraße 1, D-85764 Neuherberg/Munich, Germany.


Newcastle disease virus (NDV) causes a severe and economically significant disease affecting almost the entire poultry industry worldwide. However, factors that affect NDV replication in host cells are poorly understood. Raf kinase inhibitory protein (RKIP) is a physiological inhibitor of c-RAF kinase and NF-κB signalling, known for their functions in the control of immune response as well as tumour invasion and metastasis. In the present study, we investigated the consequences of overexpression of host RKIP during viral infection. We demonstrate that NDV infection represses RKIP expression thereby promoting virus replication. Experimental upregulation of RKIP in turn acts as a potential antiviral defence mechanism in host cells that restricts NDV replication by repressing the activation of Raf/MEK/ERK and IκBα/NF-κB signalling pathways. Our results not only extend the concept of linking NDV-host interactions, but also reveal RKIP as a new class of protein-kinase-inhibitor protein that affects NDV replication with therapeutic potential.

[Indexed for MEDLINE]

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